Ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant Staphylococcus aureus causing infective endocarditis

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Masayuki Nig, Lorena Díaz , Lina P Carvajal, etal_2017.pdf (371.9 KB)

Fecha

2017

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Publicado en

Antimicrobial agents and chemotherapy, 1098-6596, Vol. 61, Nro. 3, 2017

Publicado por

American Society for Microbiology

URI

https://hdl.handle.net/20.500.12495/3423

URL de la fuente

https://aac.asm.org/content/61/3/e01235-16

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Abstract

We report a case of infective endocarditis (IE) caused by ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant S. aureus (MRSA). Resistance to ceftaroline emerged in the absence of drug exposure, and the E447K substitution in the active site of PBP2a previously associated with ceftaroline resistance was identified. Additionally, we present evidence of patient-to-patient transmission of the strain within the same unit. This case illustrates the difficulties in treating MRSA IE in the setting of a multidrug-resistant phenotype.

Palabras clave

Keywords

Staphylococcus aureus, Ceftaroline, Endocarditis.

Temáticas

Farmacorresistencia bacteriana
Transmisión de enfermedad infecciosa
Insuficiencia del tratamiento

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