Mutations in cdsA and pgsA Correlate with Daptomycin Resistance in Streptococcus mitis and S. Oralis

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dc.contributor.authorTran, Truc T.
dc.contributor.authorMishra, Nagendra Nath
dc.contributor.authorSeepersaud, Ravin
dc.contributor.authorDiaz, Lorena
dc.contributor.authorDinh, An Q.
dc.contributor.authorGarcía-De-La-Mària, Cristina
dc.contributor.authorRybak, Michael Joseph
dc.contributor.authorMiró, José María
dc.contributor.authorShelburne, Samuel A.
dc.contributor.authorShelburne, Samuel A.
dc.contributor.authorSullam, Paul M.
dc.contributor.authorBayer, Arnold S.
dc.contributor.authorArias, César A.
dc.date.accessioned2020-03-27T17:11:57Z
dc.date.available2020-03-27T17:11:57Z
dc.date.issued2019
dc.description.abstractenglishWe investigated the ability of several recent clinical viridans group streptococci (VGS) bloodstream isolates (Streptococcus mitis/S. oralis subgroup) from daptomycin (DAP)-naive patients to develop DAP resistance in vitro. All strains rapidly developed high-level and stable DAP resistance. Substitutions in two enzymes involved in the cardiolipin biosynthesis pathway were identified, i.e., CdsA (phosphatidate cytidylyltransferase) and PgsA (CDP-diacylglycerol-glycerol-3-phosphate-3phosphatidyltransferase). These mutations were associated with complete disappearance of phosphatidylglycerol and cardiolipin from cell membranes. DAP interactions with the cell membrane differed in isolates with PgsA versus CdsA substitutionseng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1128/AAC.01531-18
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1098-6596
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2170
dc.language.isoeng
dc.publisherAmerican society for microbiologyspa
dc.publisher.journalAntimicrobial agents and chemotherapyspa
dc.relation.ispartofseriesAntimicrobial agents and chemotherapy, 1098-6596, Vol. 63, Nro. 2, 2019, p. e01531-18spa
dc.relation.urihttps://aac.asm.org/content/63/2/e01531-18.abstract
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf328
dc.rights.creativecommons2019
dc.rights.localAcceso cerradospa
dc.subject.decsStreptococcus mitispa
dc.subject.decsCardiolipinasspa
dc.subject.decsDaptomicinaspa
dc.subject.keywordsCdsAspa
dc.subject.keywordsPgsAspa
dc.subject.keywordsDaptomycin resistancespa
dc.titleMutations in cdsA and pgsA Correlate with Daptomycin Resistance in Streptococcus mitis and S. Oralisspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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Tran T.T., Mishra N.N., Seepersaud R., Diaz L., Rios R., Dinh A.Q., Garcia-de-la-Maria C., Rybak M.J., Miro J.M., Shelburne S.A., Sullam P.M., Bayer A.S., Arias C.A._2019.pdf
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