Mutations in cdsA and pgsA Correlate with Daptomycin Resistance in Streptococcus mitis and S. Oralis

Miniatura

Archivos

Tran T.T., Mishra N.N., Seepersaud R., Diaz L., Rios R., Dinh A.Q., Garcia-de-la-Maria C., Rybak M.J., Miro J.M., Shelburne S.A., Sullam P.M., Bayer A.S., Arias C.A._2019.pdf (831.16 KB)

Fecha

2019

Autores

Título de la revista

Publicado en

Antimicrobial agents and chemotherapy, 1098-6596, Vol. 63, Nro. 2, 2019, p. e01531-18

Publicado por

American society for microbiology

URI

https://hdl.handle.net/20.500.12495/2170

URL de la fuente

https://aac.asm.org/content/63/2/e01531-18.abstract

Enlace a contenidos multimedia

ISSN de la revista

Título del volumen

Resumen

Descripción

Abstract

We investigated the ability of several recent clinical viridans group streptococci (VGS) bloodstream isolates (Streptococcus mitis/S. oralis subgroup) from daptomycin (DAP)-naive patients to develop DAP resistance in vitro. All strains rapidly developed high-level and stable DAP resistance. Substitutions in two enzymes involved in the cardiolipin biosynthesis pathway were identified, i.e., CdsA (phosphatidate cytidylyltransferase) and PgsA (CDP-diacylglycerol-glycerol-3-phosphate-3phosphatidyltransferase). These mutations were associated with complete disappearance of phosphatidylglycerol and cardiolipin from cell membranes. DAP interactions with the cell membrane differed in isolates with PgsA versus CdsA substitutions

Palabras clave

Keywords

CdsA, PgsA, Daptomycin resistance

Temáticas

Streptococcus miti
Cardiolipinas
Daptomicina

Citación

Colecciones

Artículos