Risk of development of brain metastases according to the IASLC/ATS/ERS lung adenocarcinoma classification in locally advanced and metastatic disease

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dc.contributor.authorArrieta, Oscar
dc.contributor.authorAvilés Salas, Alejandro
dc.contributor.authorCardona, Andrés Felipe
dc.contributor.authorDíaz-García, Diego
dc.contributor.authorLara-Mejía, Luis
dc.contributor.authorEscamilla, Ixel
dc.contributor.authorPereira García, Ariana
dc.contributor.authorCaballé Pérez, Enrique
dc.contributor.authorEstuardo Raez, Luis
dc.contributor.authorRolfo, Christian Diego
dc.contributor.authorCosta Rosell, Rafael
dc.contributor.orcidCardona, Andrés Felipe [0000-0003-3525-4126]
dc.date.accessioned2021-03-08T17:30:48Z
dc.date.available2021-03-08T17:30:48Z
dc.date.issued2021-01-27
dc.description.abstractenglishIntroduction: Brain metastases (BM) are frequent among lung cancer patients, affecting prognosis and quality of life. The International Association for the Study of Lung Cancer (IASLC), American Thoracic Society (ATS) and European Respiratory Society (ERS) lung adenocarcinoma (LADC) classification (IASLC/ATS/ERS) has prog-nostic impact in early-stage disease; however, its role in the advanced setting is not precise. This study aims to determine the correlation between the predominant histological subtype and the risk of developing brain me-tastases (BM) in locally advanced and metastatic (stages IIIB-IV) LADC. Methods: A total of 710 patients with LADC were treated at our institution from January 2010 to December 2017. After excluding patients with brain metastases at diagnoses (n =151), they were categorized according to the IASLC/ATS/ERS LADC classification to estimate the risk of developing brain metastases. A competing risk analysis was employed, considering death a competing risk event. Results: From 559 patients, the mean age was 59 ±13.2 years, women (52.4 %), and clinical-stage IV (79.2 %). LADC subtypes distribution was lepidic (11.6 %), acinar (37.9 %), papillary (10.2 %), micropapillary (6.8 %), and solid (33.5 %). A total of 27.0 % of patients developed BM, 32.9 % died without brain affection, and 40.0 % did not progress. The predominantly solid subtype showed the greatest probability of all subtypes for developing BM [HR 4.0; 95 % CI (1.80eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.lungcan.2021.01.023
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1872-8332
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5572
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalLung cancerspa
dc.relation.ispartofseriesLung cancer, 1872-8332, 2021spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0169500221000416?via%3Dihub
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.localAcceso abiertospa
dc.subject.keywordsCentral nervous system metastasesspa
dc.subject.keywordsHistologic gradespa
dc.subject.keywordsAdenocarcinoma subtypespa
dc.subject.keywordsDifferentiation gradespa
dc.subject.keywordsLung cancerspa
dc.titleRisk of development of brain metastases according to the IASLC/ATS/ERS lung adenocarcinoma classification in locally advanced and metastatic diseasespa
dc.title.translatedRisk of development of brain metastases according to the IASLC/ATS/ERS lung adenocarcinoma classification in locally advanced and metastatic diseasespa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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