Enterococcal endocarditis: can we win the war?

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Fecha

2012

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Current infectious disease reports, 1534-3146, Vol. 14, Nro. 4, 2012, p. 339-349

Publicado por

Springer Nature

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Abstract

Treatment of enterococcal infections has long been recognized as an important clinical challenge, particularly in the setting of infective endocarditis (IE). Furthermore, the increase prevalence of isolates exhibiting multidrug resistance (MDR) to traditional anti-enterococcal antibiotics such as ampicillin, vancomycin and aminoglycosides (high-level resistance) poses immense therapeutic dilemmas in hospitals around the world. Unlike IE caused by most isolates of Enterococcus faecalis, which still retain susceptibility to ampicillin and vancomycin, the emergence and dissemination of a hospital-associated genetic clade of multidrug resistant Enterococcus faecium, markedly limits the therapeutic options. The best treatment of IE MDR enterococcal endocarditis is unknown and the paucity of antibiotics with bactericidal activity against these organisms is a cause of serious concern. Although it appears that we are winning the war against E. faecalis, the battle rages on against isolates of multidrug-resistant E. faecium.

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Keywords

Infective endocarditis, Enterococcus, Therapy

Temáticas

Enterococos resistentes a la vancomicina
Endocarditis
Microbioma gastrointestinal

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