Differential prefrontal-like deficit in children after cerebellar astrocytoma and medulloblastoma tumor

Cargando...
Miniatura

Fecha

2008

Título de la revista

Publicado en

Behavioral and Brain Functions, 1744-9081, Vol. 4, 2008, p. 1-16

Publicado por

Biomed Central

Enlace a contenidos multimedia

ISSN de la revista

Título del volumen

Resumen

Descripción

Abstract

This study was realized thanks to the collaboration of children and adolescents who had been resected from cerebellar tumors. The medulloblastoma group (CE+, n = 7) in addition to surgery received radiation and chemotherapy. The astrocytoma group (CE, n = 13) did not receive additional treatments. Each clinical group was compared in their executive functioning with a paired control group (n = 12). The performances of the clinical groups with respect to controls were compared considering the tumor's localization (vermis or hemisphere) and the affectation (or not) of the dentate nucleus. Executive variables were correlated with the age at surgery, the time between surgery-evaluation and the resected volume. The executive functioning was assessed by means of WCST, Complex Rey Figure, Controlled Oral Word Association Test (letter and animal categories), Digits span (WISC-R verbal scale) and Stroop test. These tests are very sensitive to dorsolateral PFC and/or to medial frontal cortex functions. The scores for the non-verbal Raven IQ were also obtained. Direct scores were corrected by age and transformed in standard scores using normative data. The neuropsychological evaluation was made at 3.25 (SD = 2.74) years from surgery in CE group and at 6.47 (SD = 2.77) in CE+ group.

Palabras clave

Keywords

Anterior Cingulate Cortex, Medulloblastoma, Verbal Fluency, Digit Span, Wisconsin Card Sorting Test

Temáticas

Meduloblastoma
Neoplasias neuroepiteliales
Test de clasificación de tarjetas de Wisconsin

Citación

Colecciones