Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors

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dc.contributor.authorJalali, Rozita
dc.contributor.authorGuy, Franck
dc.contributor.authorGhazanfari, Samaneh
dc.contributor.authorLyaruu, Don
dc.contributor.authorRuijven, Leo van
dc.contributor.authorDenBesten, Pamela
dc.contributor.authorMartignon, Stefania
dc.contributor.authorCastiblanco, Gina
dc.contributor.authorBronckers, Antonius L.J.J.
dc.contributor.orcidMartignon, Stefania [0000-0002-6505-8356]
dc.date.accessioned2020-08-03T14:55:53Z
dc.date.available2020-08-03T14:55:53Z
dc.description.abstractenglishObjective Fluoride excess of 0.05–0.07 mg F/kg bw/day in water or food additives like salt is the principal cause of endemic dental fluorosis. How fluoride causes these defects is not clear yet. Recent studies in rodents suggest that development of enamel fluorosis is associated with insufficient neutralization of protons released during the formation of hypermineralized lines. Design Here we examined whether hypermineralization could also be assessed by MicroCT in developing molar enamel of humans exposed to fluoride. Result Micro-CT analysis of hypomineralized enamel from human fluorotic molars graded by the Thylstrup–Fejerskov (TF) Index as III–IV showed weak hypermineralized lines and hypermineralized patches not seen in TF-I/II grade enamel. The mesio-distal sides of these molar teeth were significantly smaller (∼18%, p = 0.02) than in TF-I/II teeth. Conclusion The patterns of changes observed in human fluorotic teeth were similar to those in fluorotic rodent incisors. The data are consistent with the hypothesis that also in developing human teeth fluoride-stimulated local acidification of enamel could be a mechanism for developing fluorotic enamel.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.archoralbio.2017.07.018
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn0003-9969
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3652
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalArchives of Oral Biologyspa
dc.relation.ispartofseriesArchives of Oral Biology, 0003-9969, Vol. 83, 2017, p. 214-221spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S000399691730239X?via%3Dihub
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2017-11
dc.rights.localAcceso abiertospa
dc.subject.keywordsHypomineralizationspa
dc.subject.keywordsDental fluorosisspa
dc.subject.keywordsEnamel developmentspa
dc.subject.keywordsHypermineralizationspa
dc.titleMineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisorsspa
dc.title.translatedMineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisorsspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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