Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors
Cargando...
Archivos
Fecha
Título de la revista
Publicado en
Archives of Oral Biology, 0003-9969, Vol. 83, 2017, p. 214-221
Publicado por
Elsevier
Enlace a contenidos multimedia
ISSN de la revista
Título del volumen
Resumen
Descripción
Abstract
Objective
Fluoride excess of 0.05–0.07 mg F/kg bw/day in water or food additives like salt is the principal cause of endemic dental fluorosis. How fluoride causes these defects is not clear yet. Recent studies in rodents suggest that development of enamel fluorosis is associated with insufficient neutralization of protons released during the formation of hypermineralized lines.
Design
Here we examined whether hypermineralization could also be assessed by MicroCT in developing molar enamel of humans exposed to fluoride.
Result
Micro-CT analysis of hypomineralized enamel from human fluorotic molars graded by the Thylstrup–Fejerskov (TF) Index as III–IV showed weak hypermineralized lines and hypermineralized patches not seen in TF-I/II grade enamel. The mesio-distal sides of these molar teeth were significantly smaller (∼18%, p = 0.02) than in TF-I/II teeth.
Conclusion
The patterns of changes observed in human fluorotic teeth were similar to those in fluorotic rodent incisors. The data are consistent with the hypothesis that also in developing human teeth fluoride-stimulated local acidification of enamel could be a mechanism for developing fluorotic enamel.
Palabras clave
Keywords
Hypomineralization, Dental fluorosis, Enamel development, Hypermineralization