Distinct genetic diversity of carbapenem-resistant acinetobacter baumannii from Colombian hospitals

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dc.contributor.authorCorrea, Adriana
dc.contributor.authordel Campo, Rosa
dc.contributor.authorEscandón-Vargas, Kevin
dc.contributor.authorPerenguez, Marcela
dc.contributor.authorRodríguez-Baños, Mercedes
dc.contributor.authorHernández-Gómez, Cristhian
dc.contributor.authorPallares, Christian José
dc.contributor.authorPerez, Federico
dc.contributor.authorArias, Cesar A.
dc.contributor.authorCantón, Rafael
dc.contributor.authorVillegas, María Virginia
dc.contributor.orcidPallares, Christian José [0000-0002-6093-7845]
dc.contributor.orcidVillegas, María Virginia [0000-0003-1898-9067]
dc.date.accessioned2020-05-18T04:38:56Z
dc.date.available2020-05-18T04:38:56Z
dc.date.issued2018
dc.description.abstractenglishThe global success of multidrug-resistant Acinetobacter baumannii has been associated with the dissemination of a high-risk clone designated clonal complex (CC) 92B (Bartual scheme)/CC2P (Pasteur scheme), which is the most frequent genetic lineage in European, Asian, and North American carbapenem-resistant Acinetobacter isolates. In these isolates, carbapenem resistance is mainly mediated by β-lactamases encoded by blaOXA-23-like, blaOXA-24-like, blaOXA-51-like, and/or blaOXA-58-like genes. In this study, we characterized the population genetics of 121 carbapenem-resistant A. baumannii complex isolates recovered from 14 hospitals in seven cities in Colombia (2008–2010). Multiplex PCR was used to detect blaOXA-23-like, blaOXA-24-like, blaOXA-51-like, and blaOXA-58-like genes. Molecular typing was performed using pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). PCR showed that 118 (97.5%) of the isolates were positive for both blaOXA-23-like and blaOXA-51-like genes, and three other isolates were only positive for blaOXA-51-like. PFGE identified 18 different pulsotypes, while MLST identified 11 different sequence types (STs), seven of which had not been previously described in Acinetobacter. None of the STs found in this study was associated with CC92B/CC2P. The most widespread STs in our isolates belonged to ST636 and their single-locus variants ST121/ST124/ST634 (CC636B) followed by STs belonging to CC110B. Our observations suggest a wide distribution of diverse A. baumannii complex clones containing blaOXA-23-like in Colombian hospitals (especially CC636B and CC110B) that differ from the high-risk clones commonly found in other regions of the world, indicating a distinct molecular epidemiology of carbapenem-resistant Acinetobacter spp. in Colombia.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1089/mdr.2016.0190
dc.identifier.issn1076-6294
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2893
dc.language.isoeng
dc.publisherMary Ann Liebertspa
dc.publisher.journalMicrobial Drug Resistancespa
dc.relation.ispartofseriesMicrobial Drug Resistance, 1076-6294, Vol 24, Num 1, 2018, pag 48-54spa
dc.relation.urihttps://www.liebertpub.com/doi/abs/10.1089/mdr.2016.0190?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=mdr
dc.rights.creativecommons2018
dc.rights.localAcceso cerradospa
dc.subject.decsResistencia a medicamentosspa
dc.subject.decsBacilos y cocos aerobios gramnegativosspa
dc.subject.decsTécnicas de tipificación bacterianaspa
dc.subject.keywordsAcinetobacter baumanniispa
dc.subject.keywordsAntibiotic resistancespa
dc.subject.keywordsCarbapenemasespa
dc.subject.keywordsOXA enzymesspa
dc.subject.keywordsMultilocus sequence typingspa
dc.titleDistinct genetic diversity of carbapenem-resistant acinetobacter baumannii from Colombian hospitalsspa
dc.title.translatedDistinct genetic diversity of carbapenem-resistant acinetobacter baumannii from Colombian hospitalsspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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