Family history as a risk factor for herpes zoster: A case-control study

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dc.contributor.authorHicks, Lindsey
dc.contributor.authorCook-Norris, Robert H.
dc.contributor.authorMadkan, Vandana
dc.contributor.authorMendoza, Natalia
dc.contributor.authorArora, Anita
dc.contributor.authorTyring, Stephen
dc.date.accessioned2020-05-14T19:19:07Z
dc.date.available2020-05-14T19:19:07Z
dc.date.issued2015
dc.description.abstractenglishObjective: To assess risk factors for herpes zoster beyond age and immunosuppression, especially the association with a family history of herpes zoster, since a preventative herpes zoster and postherpetic neuralgia vaccine is now available. Design: We undertook a case-control study of herpes zoster, which represents reactivation of latent varicella zoster virus residing in dorsal root ganglia following primary infection, involving 504 patients and 523 controls. Interviews were conducted by trained medical investigators using a structured questionnaire. Setting: The Center for Clinical Studies, an outpatient clinic and research center in Houston, Texas. Participants: Non immunocompromised patients with confirmed cases of herpes zoster were included in the study. Controls were nonimmunocompromised clinic patients with new diagnoses of skin diseases other than herpes zoster. Results: Cases were more likely to report blood relatives with a history of zoster (39%) compared with controls (11%; P.001). Risk was increased with multiple blood relatives (odds ratio, 13.77; 95% confidence interval, 5.85-32.39) compared with single blood relatives (odds ratio, 4.50; 95% confidence interval, 3.15-6.41). Conclusions: The results suggest an association between herpes zoster and family history of zoster. Futurestudies will be needed to investigate this association.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1001/archderm.144.5.603
dc.identifier.issn0003-987X
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2783
dc.language.isoeng
dc.publisherAmerican Medical Associationspa
dc.publisher.journalArchives of dermatologyspa
dc.relation.ispartofseriesArchives of dermatology, 0003-987X, Vol.114, Nro.5, 2015, p.603-608spa
dc.relation.urihttps://jamanetwork.com/journals/jamadermatology/article-abstract/419703
dc.rights.creativecommons2008
dc.rights.localAcceso cerradospa
dc.subject.decsHerpes Zósterspa
dc.subject.decsNeuralgia posherpéticaspa
dc.subject.decsEstudio clínicospa
dc.titleFamily history as a risk factor for herpes zoster: A case-control studyspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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