Family history as a risk factor for herpes zoster: A case-control study

Cargando...
Miniatura

Fecha

2015

Título de la revista

Publicado en

Archives of dermatology, 0003-987X, Vol.114, Nro.5, 2015, p.603-608

Publicado por

American Medical Association

Enlace a contenidos multimedia

ISSN de la revista

Título del volumen

Resumen

Descripción

Abstract

Objective: To assess risk factors for herpes zoster beyond age and immunosuppression, especially the association with a family history of herpes zoster, since a preventative herpes zoster and postherpetic neuralgia vaccine is now available. Design: We undertook a case-control study of herpes zoster, which represents reactivation of latent varicella zoster virus residing in dorsal root ganglia following primary infection, involving 504 patients and 523 controls. Interviews were conducted by trained medical investigators using a structured questionnaire. Setting: The Center for Clinical Studies, an outpatient clinic and research center in Houston, Texas. Participants: Non immunocompromised patients with confirmed cases of herpes zoster were included in the study. Controls were nonimmunocompromised clinic patients with new diagnoses of skin diseases other than herpes zoster. Results: Cases were more likely to report blood relatives with a history of zoster (39%) compared with controls (11%; P.001). Risk was increased with multiple blood relatives (odds ratio, 13.77; 95% confidence interval, 5.85-32.39) compared with single blood relatives (odds ratio, 4.50; 95% confidence interval, 3.15-6.41). Conclusions: The results suggest an association between herpes zoster and family history of zoster. Futurestudies will be needed to investigate this association.

Palabras clave

Keywords

Temáticas

Herpes Zóster
Neuralgia posherpética
Estudio clínico

Citación

Colecciones