Chronic consumption of a healthy diet interacts with the clock gene locus to modify glucose metabolism among metabolic syndrome patients from the CORDIOPREV intervention study

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dc.contributor.authorGarcía Ríos, Antonio
dc.contributor.authorAlcalá Díaz, Juan Francisco
dc.contributor.authorGómez Delgado, Francisco
dc.contributor.authorCamargo García, Antonio
dc.contributor.authorQuintana Navarro, Gracia María
dc.contributor.authorGómez Luna, Purificación
dc.contributor.authorLópez Miranda, José
dc.contributor.authorPérez Martínez, Pablo
dc.date.accessioned2022-11-02T12:57:34Z
dc.date.available2022-11-02T12:57:34Z
dc.date.issued2013
dc.description.abstractenglishIntroduction: Circadian Locomotor Output Cycles Kaput (CLOCK) gene has been related with lifestyle-related diseases such as obesity, metabolic syndrome (MetS), and cardiovascular diseases. Hypothesis: We assessed wheter the chronic consumption of a Mediterranean diet enriched in olive oil, compared with a Low fat diet, interacts with three common single nucleotide polymorphisms (SNPs) at CLOCK locus (rs1801260, rs3749474, and rs4580704) in order to improve glucose metabolism among MetS patients. Methods: Index related with glucose metabolism ((the homeostasis model assessment of insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI)), insulin concentrations, and CLOCK SNPs were determined in 581 MetS subjects from the CORDIOPREV clinical trial (NCT00924937). Gene-diet interactions were analysed after one year of dietary treatment (Mediterranean diet (38% fat, 22% MUFA) vs Low fat diet (<28% fat, 12% MUFA)). Results: We found a gene-diet interaction between rs1801260 SNP and dietary pattern for insulin concentrations (P=0.009), HOMA-IR (P=0.014) and QUICKI (P=0.028). Specifically, after 12 months of Low fat intervention, homozygous for the major allele (AA) displayed lower plasma insulin concentrations (P=0.032), lower insulin resistance (HOMA-IR; P=0.027) and higher sensibility of insulin (QUICKI index; P=0.024) compared with carriers of the minor allele G (AG+GG). No other gene-diet interactions were found. Conclusions: Chronic consumption of a healthy diet may play a contributing role in triggering glucose metabolism by interacting with the rs1801260 SNP at CLOCK gene locus in MetS patients. Due to the complex nature of gene-environment interactions, dietary adjustment in subject with the MetS may require a personalized approach.eng
dc.format.mimetypeapplication/pdf
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1524-4539
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/9259
dc.language.isoeng
dc.publisherAmerican Heart Associationspa
dc.publisher.journalCirculationspa
dc.relation.ispartofseriesCirculation, 1524-4539, Vol. 128, Supl. 22, 2013, Abstract 11239spa
dc.relation.urihttps://www.ahajournals.org/doi/abs/10.1161/circ.128.suppl_22.A11239
dc.rights.accessrightshttps://purl.org/coar/access_right/c_14cb
dc.rights.accessrightsinfo:eu-repo/semantics/closedAccess
dc.rights.accessrightsAcceso cerrado
dc.subjectResistencia a la insulinaspa
dc.subjectSíndrome metabólicospa
dc.subjectGenéticaspa
dc.subject.keywordsInsulin resistancespa
dc.subject.keywordsMetabolic syndromespa
dc.subject.keywordsGeneticsspa
dc.titleChronic consumption of a healthy diet interacts with the clock gene locus to modify glucose metabolism among metabolic syndrome patients from the CORDIOPREV intervention studyspa
dc.title.translatedChronic consumption of a healthy diet interacts with the clock gene locus to modify glucose metabolism among metabolic syndrome patients from the CORDIOPREV intervention studyspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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