Chronic consumption of a healthy diet interacts with the clock gene locus to modify glucose metabolism among metabolic syndrome patients from the CORDIOPREV intervention study
Fecha
2013
Título de la revista
Publicado en
Circulation, 1524-4539, Vol. 128, Supl. 22, 2013, Abstract 11239
Publicado por
American Heart Association
URL de la fuente
Enlace a contenidos multimedia
ISSN de la revista
Título del volumen
Resumen
Descripción
Abstract
Introduction: Circadian Locomotor Output Cycles Kaput (CLOCK) gene has been related with lifestyle-related diseases such as obesity, metabolic syndrome (MetS), and cardiovascular diseases. Hypothesis: We assessed wheter the chronic consumption of a Mediterranean diet enriched in olive oil, compared with a Low fat diet, interacts with three common single nucleotide polymorphisms (SNPs) at CLOCK locus (rs1801260, rs3749474, and rs4580704) in order to improve glucose metabolism among MetS patients. Methods: Index related with glucose metabolism ((the homeostasis model assessment of insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI)), insulin concentrations, and CLOCK SNPs were determined in 581 MetS subjects from the CORDIOPREV clinical trial (NCT00924937). Gene-diet interactions were analysed after one year of dietary treatment (Mediterranean diet (38% fat, 22% MUFA) vs Low fat diet (<28% fat, 12% MUFA)). Results: We found a gene-diet interaction between rs1801260 SNP and dietary pattern for insulin concentrations (P=0.009), HOMA-IR (P=0.014) and QUICKI (P=0.028). Specifically, after 12 months of Low fat intervention, homozygous for the major allele (AA) displayed lower plasma insulin concentrations (P=0.032), lower insulin resistance (HOMA-IR; P=0.027) and higher sensibility of insulin (QUICKI index; P=0.024) compared with carriers of the minor allele G (AG+GG). No other gene-diet interactions were found. Conclusions: Chronic consumption of a healthy diet may play a contributing role in triggering glucose metabolism by interacting with the rs1801260 SNP at CLOCK gene locus in MetS patients. Due to the complex nature of gene-environment interactions, dietary adjustment in subject with the MetS may require a personalized approach.
Palabras clave
Resistencia a la insulina, Síndrome metabólico, Genética
Keywords
Insulin resistance, Metabolic syndrome, Genetics