ARGONAUT II study of the in vitro activity of plazomicin against carbapenemase-producing klebsiella pneumoniae

dc.contributor.authorJacobs, Michael R.
dc.contributor.authorGood, Caryn E.
dc.contributor.authorHujer, Andrea M.
dc.contributor.authorAbdelhamed, Ayman M.
dc.contributor.authorRhoads, Daniel
dc.contributor.authorHujer, Kristine M.
dc.contributor.authorRudin, Susan D.
dc.contributor.authorDomitrovic, T. Nicholas J.
dc.contributor.authorConnolly, Lynn E.
dc.contributor.authorKrause, Kevin M.
dc.contributor.authorPatel, Robin
dc.contributor.authorArias, Cesar A
dc.contributor.authorKreiswirth, Barry N.
dc.contributor.authorRojas, Laura J.
dc.contributor.authorD'Souza, Roshan
dc.contributor.authorKing, C. Richard
dc.contributor.authorBrinkac, Lauren M.
dc.contributor.authorNguyen, Kevin
dc.contributor.authorSingh, Indresh
dc.contributor.authorFouts, Derrick E.
dc.contributor.authorvan Duin, David
dc.contributor.authorBonomo, Robert A.
dc.date.accessioned2020-07-15T17:59:35Z
dc.date.available2020-07-15T17:59:35Z
dc.date.issued2020
dc.description.abstractenglishPlazomicin was tested against 697 recently acquired carbapenem-resistant Klebsiella pneumoniae isolates from the Great Lakes region of the United States. Plazomicin MIC50 and MIC90 values were 0.25 and 1 mg/liter, respectively; 680 isolates (97.6%) were susceptible (MICs of ≤2 mg/liter), 9 (1.3%) intermediate (MICs of 4 mg/liter), and 8 (1.1%) resistant (MICs of >32 mg/liter). Resistance was associated with rmtF-, rmtB-, or armA-encoded 16S rRNA methyltransferases in all except 1 isolate.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1128/aac.00012-20
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1098-6596
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3501
dc.language.isoeng
dc.publisherAmerican Society for Microbiologyspa
dc.publisher.journalAntimicrobial agents and chemotherapyspa
dc.relation.ispartofseriesAntimicrobial agents and chemotherapy, 1098-6596, Vol. 64, Nro. 5, 2020spa
dc.relation.urihttps://aac.asm.org/content/64/5/e00012-20.long
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2020-04-21
dc.rights.localAcceso abiertospa
dc.subject.decsEnterobacteriaceae resistentes a los carbapenémicosspa
dc.subject.decsCarbapenémicosspa
dc.subject.decsProteínas asociadas a resistencia a múltiples medicamentosspa
dc.subject.keywordsKlebsiellaspa
dc.subject.keywordsAntibiotic resistancespa
dc.subject.keywordsCarbapenemasespa
dc.titleARGONAUT II study of the in vitro activity of plazomicin against carbapenemase-producing klebsiella pneumoniaespa
dc.title.translatedARGONAUT II study of the in vitro activity of plazomicin against carbapenemase-producing klebsiella pneumoniaespa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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