ARGONAUT II study of the in vitro activity of plazomicin against carbapenemase-producing klebsiella pneumoniae

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Fecha

2020

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Título de la revista

Publicado en

Antimicrobial agents and chemotherapy, 1098-6596, Vol. 64, Nro. 5, 2020

Publicado por

American Society for Microbiology

URI

https://hdl.handle.net/20.500.12495/3501

URL de la fuente

https://aac.asm.org/content/64/5/e00012-20.long

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Descripción

Abstract

Plazomicin was tested against 697 recently acquired carbapenem-resistant Klebsiella pneumoniae isolates from the Great Lakes region of the United States. Plazomicin MIC50 and MIC90 values were 0.25 and 1 mg/liter, respectively; 680 isolates (97.6%) were susceptible (MICs of ≤2 mg/liter), 9 (1.3%) intermediate (MICs of 4 mg/liter), and 8 (1.1%) resistant (MICs of >32 mg/liter). Resistance was associated with rmtF-, rmtB-, or armA-encoded 16S rRNA methyltransferases in all except 1 isolate.

Palabras clave

Keywords

Klebsiella, Antibiotic resistance, Carbapenemase

Temáticas

Enterobacteriaceae resistentes a los carbapenémicos
Carbapenémicos
Proteínas asociadas a resistencia a múltiples medicamentos

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