Expression of the major and pro-Oncogenic H3K9 lysine methyltransferase SETDB1 in non-Small cell lung cancer

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dc.contributor.authorCruz-Tapias, Paola
dc.contributor.authorZakharova, Vlada
dc.contributor.authorPerez-Fernandez, Oscar M.
dc.contributor.authorMantilla, William
dc.contributor.authorRamírez-Clavijo, Sandra
dc.contributor.authorAit-Si-Ali, Slimane
dc.date.accessioned2021-06-23T18:02:45Z
dc.date.available2021-06-23T18:02:45Z
dc.date.issued2019-08-08
dc.description.abstractenglishSETDB1 is a key histone lysine methyltransferase involved in gene silencing. The SETDB1 gene is amplified in human lung cancer, where the protein plays a driver role. Here, we investigated the clinical significance of SETDB1 expression in the two major forms of human non-small cell lung carcinoma (NSCLC), i.e., adenocarcinoma (ADC) and squamous cell carcinoma (SCC), by combining a meta-analysis of transcriptomic datasets and a systematic review of the literature. A total of 1140 NSCLC patients and 952 controls were included in the association analyses. Our data revealed higher levels of SETDB1 mRNA in ADC (standardized mean difference, SMD: 0.88; 95% confidence interval, CI: 0.73–1.02; p < 0.001) and SCC (SMD: 0.40; 95% CI: 0.13–0.66; p = 0.003) compared to non-cancerous tissues. For clinicopathological analyses, 2533 ADC and 903 SCC patients were included. Interestingly, SETDB1 mRNA level was increased in NSCLC patients who were current smokers compared to non-smokers (SMD: 0.26; 95% CI: 0.08–0.44; p = 0.004), and when comparing former smokers and non-smokers (p = 0.009). Furthermore, the area under the curve (AUC) given by the summary receiver operator characteristic curve (sROC) was 0.774 (Q = 0.713). Together, our findings suggest a strong foundation for further research to evaluate SETDB1 as a diagnostic biomarker and/or its potential use as a therapeutic target in NSCLC.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/cancers11081134
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2072-6694
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5899
dc.language.isoeng
dc.publisherMDPIspa
dc.publisher.journalCancersspa
dc.relation.ispartofseriesCancers, 2072-6694, Vol. 11, No. 08, 2019, Art. 1134spa
dc.relation.urihttps://www.mdpi.com/2072-6694/11/8/1134
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.keywordsSETDB1/KMT1Espa
dc.subject.keywordsLysine methyltransferasespa
dc.subject.keywordsNon-small cell lung cancerspa
dc.subject.keywordsMeta-analysisspa
dc.titleExpression of the major and pro-Oncogenic H3K9 lysine methyltransferase SETDB1 in non-Small cell lung cancerspa
dc.title.translatedExpression of the major and pro-Oncogenic H3K9 lysine methyltransferase SETDB1 in non-Small cell lung cancerspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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