Small cell lung cancer: State of the art of the molecular and genetic landscape and novel perspective

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dc.contributor.authorDenninghoff, Valeria
dc.contributor.authorRusso, Alessandro
dc.contributor.authorMiguel Pérez, Diego de
dc.contributor.authorMalapelle, Umberto
dc.contributor.authorBenyounes, Amin
dc.contributor.authorGittens, Allison
dc.contributor.authorCardona, Andres Felipe
dc.contributor.authorRolfo, Christian
dc.contributor.orcidDenninghoff, Valeria [0000-0002-3309-7801]
dc.contributor.orcidRusso, Alessandro [0000-0002-3365-1972]
dc.contributor.orcidMiguel Pérez, Diego de [0000-0002-2822-4466]
dc.contributor.orcidMalapelle, Umberto [0000-0003-3211-9957]
dc.date.accessioned2021-05-10T17:35:28Z
dc.date.available2021-05-10T17:35:28Z
dc.date.issued2021-04-01
dc.description.abstractenglishSmall cell lung cancer (SCLC) is a highly proliferative lung cancer that is not amenable to surgery in most cases due to the high metastatic potential. Precision medicine has not yet improved patients’ survival due to the lack of actionable mutations. Intra- and intertumoral heterogeneity allow the neoplasms to adapt to various microenvironments and treatments. Further studying this heterogeneous cancer might yield the discovery of actionable mutations. First-line SCLC treatment has added immunotherapy to its armamentarium. There has been renewed interest in SCLC, and numerous clinical trials are underway with novel therapeutic approaches. Understanding the molecular and genetic landscape of this heterogeneous and lethal disease will pave the way for novel drug development.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/cancers13071723
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2072-6694
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5849
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)spa
dc.publisher.journalCancersspa
dc.relation.ispartofseriesCancers, 2072-6694, Vol. 13, Nro. 7, 2021spa
dc.relation.urihttps://www.mdpi.com/2072-6694/13/7/1723
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.keywordsSmall cell lung cancerspa
dc.subject.keywordsGene pathwayspa
dc.subject.keywordsPathobiologyspa
dc.subject.keywordsTargeted therapyspa
dc.titleSmall cell lung cancer: State of the art of the molecular and genetic landscape and novel perspectivespa
dc.title.translatedSmall cell lung cancer: State of the art of the molecular and genetic landscape and novel perspectivespa
dc.type.coarversionhttps://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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