Small cell lung cancer: State of the art of the molecular and genetic landscape and novel perspective

Cargando...
Miniatura

Fecha

2021-04-01

Título de la revista

Publicado en

Cancers, 2072-6694, Vol. 13, Nro. 7, 2021

Publicado por

Multidisciplinary Digital Publishing Institute (MDPI)

Enlace a contenidos multimedia

ISSN de la revista

Título del volumen

Resumen

Descripción

Abstract

Small cell lung cancer (SCLC) is a highly proliferative lung cancer that is not amenable to surgery in most cases due to the high metastatic potential. Precision medicine has not yet improved patients’ survival due to the lack of actionable mutations. Intra- and intertumoral heterogeneity allow the neoplasms to adapt to various microenvironments and treatments. Further studying this heterogeneous cancer might yield the discovery of actionable mutations. First-line SCLC treatment has added immunotherapy to its armamentarium. There has been renewed interest in SCLC, and numerous clinical trials are underway with novel therapeutic approaches. Understanding the molecular and genetic landscape of this heterogeneous and lethal disease will pave the way for novel drug development.

Palabras clave

Keywords

Small cell lung cancer, Gene pathway, Pathobiology, Targeted therapy

Temáticas

Citación

Colecciones