Efficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model

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dc.contributor.authorSingh, Kavindra V.
dc.contributor.authorArias, Cesar A.
dc.contributor.orcidBeral, Valerie E. [https://orcid.org/0000-0002-3581-9361]
dc.date.accessioned2022-03-07T21:08:57Z
dc.date.available2022-03-07T21:08:57Z
dc.date.issued2021
dc.description.abstractenglishOmadacycline (OMC) showed better in vitro potency than daptomycin (DAP) or vancomycin (VAN) against Vanr, Ampr, DAP-nonsusceptible, linezolid-resistant, cfr(B)1 Enterococcus faecium strains. In a mouse peritonitis model, OMC also showed significantly better animal survival during the study and at its end than DAP or VAN with these E. faecium strains. However, OMC, DAP, and VAN showed comparable in vitro and in vivo efficacies against a non-vancomycin-resistant, tetracycline-resistant, DAP-susceptible E. faecium strain.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1128/AAC.00709-21
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn0066-4804
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/7160
dc.language.isoeng
dc.publisherAmerican Society for Microbiologyspa
dc.publisher.journalAntimicrobial Agents and Chemotherapyspa
dc.relation.ispartofseriesAntimicrobial Agents and Chemotherapy, 0066-4804, Vol 65, Num 9, 2021spa
dc.relation.urihttps://journals.asm.org/doi/10.1128/AAC.00709-21
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.localAcceso abiertospa
dc.subject.keywordsE. faeciumspa
dc.subject.keywordsMouse peritonitisspa
dc.subject.keywordsOmadacyclinespa
dc.titleEfficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis modelspa
dc.title.translatedEfficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis modelspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.coarversionhttps://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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