Efficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model

Cargando...
Miniatura

Fecha

2021

Título de la revista

Publicado en

Antimicrobial Agents and Chemotherapy, 0066-4804, Vol 65, Num 9, 2021

Publicado por

American Society for Microbiology

Enlace a contenidos multimedia

ISSN de la revista

Título del volumen

Resumen

Descripción

Abstract

Omadacycline (OMC) showed better in vitro potency than daptomycin (DAP) or vancomycin (VAN) against Vanr, Ampr, DAP-nonsusceptible, linezolid-resistant, cfr(B)1 Enterococcus faecium strains. In a mouse peritonitis model, OMC also showed significantly better animal survival during the study and at its end than DAP or VAN with these E. faecium strains. However, OMC, DAP, and VAN showed comparable in vitro and in vivo efficacies against a non-vancomycin-resistant, tetracycline-resistant, DAP-susceptible E. faecium strain.

Palabras clave

Keywords

E. faecium, Mouse peritonitis, Omadacycline

Temáticas

Citación

Colecciones