The rabies virus phosphoprotein synthesis and subcellular localization are modified by nerve growth factor
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Fecha
2009
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International Journal of Neuroscience., 1543-5245, Vol. 119, Nro. 5, 2009 p. 733-743
Publicado por
Taylor & Francis
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Abstract
Rabies virus P protein participates as a regulating factor in viral transcription and replication; recent studies found an antitranscriptional and antireplicative effect of nerve growth factor (NGF) and Neurotrophin-3 (NT-3) in infected neuron cultures. We investigated here the specific effect of the neurotrophins on P protein, evaluating its synthesis and subcellular distribution in adult mouse dorsal root ganglia neuron cultures infected and treated with NGF or NT-3. The results showed that NGF, but not NT-3, caused an increase in the quantity of P protein and an accumulation of protein in neuronal bodies, revealing changes in transport to the neuritic processes.
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Keywords
Antiviral, Nerve Growth Factor (NGF), Neurotrophin-3, Rabies virus, Rabies virus phosphoprotein, Sensory neurons