The rabies virus phosphoprotein synthesis and subcellular localization are modified by nerve growth factor

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dc.contributor.authorCastañeda, Nadia Y.
dc.contributor.authorChaparro-Olaya, Jacqueline
dc.contributor.authorAcosta, Orlando
dc.contributor.authorCastellanos, Jaime
dc.contributor.orcidCastellanos, Jaime [0000-0003-1596-8383]
dc.contributor.orcidChaparro-Olaya, Jacqueline [0000-0001-9815-3459]
dc.date.accessioned2020-11-23T17:20:35Z
dc.date.available2020-11-23T17:20:35Z
dc.date.issued2009
dc.description.abstractenglishRabies virus P protein participates as a regulating factor in viral transcription and replication; recent studies found an antitranscriptional and antireplicative effect of nerve growth factor (NGF) and Neurotrophin-3 (NT-3) in infected neuron cultures. We investigated here the specific effect of the neurotrophins on P protein, evaluating its synthesis and subcellular distribution in adult mouse dorsal root ganglia neuron cultures infected and treated with NGF or NT-3. The results showed that NGF, but not NT-3, caused an increase in the quantity of P protein and an accumulation of protein in neuronal bodies, revealing changes in transport to the neuritic processes.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1080/00207450802324291
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1543-5245
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5114
dc.language.isoeng
dc.publisherTaylor & Francisspa
dc.publisher.journalInternational Journal of Neurosciencespa
dc.relation.ispartofseriesInternational Journal of Neuroscience., 1543-5245, Vol. 119, Nro. 5, 2009 p. 733-743spa
dc.relation.urihttps://www.tandfonline.com/doi/abs/10.1080/00207450802324291
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2009-07
dc.rights.localAcceso abiertospa
dc.subject.keywordsAntiviralspa
dc.subject.keywordsNerve Growth Factor (NGF)spa
dc.subject.keywordsNeurotrophin-3spa
dc.subject.keywordsRabies virusspa
dc.subject.keywordsRabies virus phosphoproteinspa
dc.subject.keywordsSensory neuronsspa
dc.titleThe rabies virus phosphoprotein synthesis and subcellular localization are modified by nerve growth factorspa
dc.title.translatedThe rabies virus phosphoprotein synthesis and subcellular localization are modified by nerve growth factorspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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