Bacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities
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Fecha
2020
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Antimicrobial agents and chemotherapy, 1098-6596, Vol. 64, Nro. 9, 2020
Publicado por
American Society for Microbiology
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Abstract
Concerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate novel therapies for Enterococcus faecium infections. Obligately lytic bacteriophages are viruses that target, infect, and kill bacterial cells. Limited studies have evaluated phage-antibiotic combinations against E. faecium After an initial screen of eight E. faecium strains, three strains with varying DAP/phage susceptibilities were selected for further experiments. Phage-to-strain specificity contributed to synergy with antibiotics by time-kill analyses and was associated with lower development of phage resistance.
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Keywords
Bacteriophage-antibiotic combinations, Bacteriophages, Daptomycin, Enterococcus faecium