Bacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities

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dc.contributor.authorMorrisette, Taylor
dc.contributor.authorLev, Katherine L.
dc.contributor.authorKebriaei, Razieh
dc.contributor.authorAbdul-Mutakabbir, Jacinda C.
dc.contributor.authorStamper, Kyle
dc.contributor.authorMorales, Sandra
dc.contributor.authorLehman, Susan
dc.contributor.authorCanfield, Gregory
dc.contributor.authorDuerkop, Breck
dc.contributor.authorArias, César A.
dc.contributor.authorRybak, Michael Joseph
dc.date.accessioned2020-09-01T23:46:25Z
dc.date.available2020-09-01T23:46:25Z
dc.date.issued2020
dc.description.abstractenglishConcerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate novel therapies for Enterococcus faecium infections. Obligately lytic bacteriophages are viruses that target, infect, and kill bacterial cells. Limited studies have evaluated phage-antibiotic combinations against E. faecium After an initial screen of eight E. faecium strains, three strains with varying DAP/phage susceptibilities were selected for further experiments. Phage-to-strain specificity contributed to synergy with antibiotics by time-kill analyses and was associated with lower development of phage resistance.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1128/aac.00993-20
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1098-6596
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3914
dc.language.isoeng
dc.publisherAmerican Society for Microbiologyspa
dc.publisher.journalAntimicrobial agents and chemotherapyspa
dc.relation.ispartofseriesAntimicrobial agents and chemotherapy, 1098-6596, Vol. 64, Nro. 9, 2020spa
dc.relation.urihttps://aac.asm.org/content/64/9/e00993-20.abstract
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2020-08-20
dc.rights.localAcceso abiertospa
dc.subject.keywordsBacteriophage-antibiotic combinationsspa
dc.subject.keywordsBacteriophagesspa
dc.subject.keywordsDaptomycinspa
dc.subject.keywordsEnterococcus faeciumspa
dc.titleBacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilitiesspa
dc.title.translatedBacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilitiesspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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