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    Targeting cell membrane adaptation as a novel antimicrobial strategy

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    TY - GEN T1 - Targeting cell membrane adaptation as a novel antimicrobial strategy UR - http://hdl.handle.net/20.500.12495/3542 PB - Elsevier AB - ER - @misc{20.500.12495_3542, author = {}, title = {Targeting cell membrane adaptation as a novel antimicrobial strategy}, year = {}, abstract = {}, url = {http://hdl.handle.net/20.500.12495/3542} }RT Generic T1 Targeting cell membrane adaptation as a novel antimicrobial strategy LK http://hdl.handle.net/20.500.12495/3542 PB Elsevier AB OL Spanish (121)
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    Author
    Tran, Truc T.
    Miller, William R. 
    Shamoo, Yousif 
    Arias, César A.
    Date
    2016-07-25
    Published in
    Current opinion in microbiology, 1879-0364, Vol. 33, 2016, p. 91-96
    Published for
    Elsevier
    URI
    http://hdl.handle.net/20.500.12495/3542
    Source's URL
    https://www.sciencedirect.com/science/article/abs/pii/S136952741630090X?via%3Dihub
    DOI
    https://doi.org/10.1016/j.mib.2016.07.002

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    Abstract
    Emergence of antibiotic resistance is an example of the incredible plasticity of bacteria to survive in all environments. The search for new antibiotics active against traditional targets is more challenging due not only to the lack of novel natural products to fulfill the current clinical needs against multidrug-resistant (MDR) bacteria, but also for the possible ‘collateral’ effects on the human microbiota. Thus, non-traditional approaches to combat MDR bacteria have been proposed. Here, we discuss the possibility of targeting the membrane response to the antibiotic attack (cell membrane adaptation) as a viable strategy to increase the activity of current antimicrobials, enhance the activity of the innate immune system and prevent development of resistance during therapy using the three-component regulatory system LiaFSR of enterococci as a model.
    Topics
    Bacitracina
    Catelicidinas
    Enterococcus faecium
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