Rationale and study design for an individualized perioperative open lung ventilatory strategy in patients on one-lung ventilation (iPROVE-OLV).

Miniatura

Archivos

Carraminana. Albert.pdf (1.21 MB)

Fecha

2019

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Título de la revista

Publicado en

Journal of cardiothoracic and vascular anesthesia, 1053-0770, Vol 33, Num 9, 2019, pag 2492-2502

Publicado por

Elsevier

URI

https://hdl.handle.net/20.500.12495/2799

URL de la fuente

https://www.jcvaonline.com/article/S1053-0770(19)30092-8/fulltext

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Resumen

Descripción

Abstract

Objective The aim of this clinical trial is to examine whether it is possible to reduce postoperative complications using an individualized perioperative ventilatory strategy versus using a standard lung-protective ventilation strategy in patients scheduled for thoracic surgery requiring one-lung ventilation. Design International, multicenter, prospective, randomized controlled clinical trial. Setting A network of university hospitals. Participants The study comprises 1,380 patients scheduled for thoracic surgery. Interventions The individualized group will receive intraoperative recruitment maneuvers followed by individualized positive end-expiratory pressure (open lung approach) during the intraoperative period plus postoperative ventilatory support with high-flow nasal cannula, whereas the control group will be managed with conventional lung-protective ventilation. Measurements and Main Results Individual and total number of postoperative complications, including atelectasis, pneumothorax, pleural effusion, pneumonia, acute lung injury; unplanned readmission and reintubation; length of stay and death in the critical care unit and in the hospital will be analyzed for both groups. The authors hypothesize that the intraoperative application of an open lung approach followed by an individual indication of high-flow nasal cannula in the postoperative period will reduce pulmonary complications and length of hospital stay in high-risk surgical patients.

Palabras clave

Keywords

Mechanical ventilation, Postoperative pulmonary complications, One-lung ventilation, Positive end-expiratory pressure, Recruitment maneuvers

Temáticas

Pulmón
Respiración
Cirugía

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