Rationale and study design for an individualized perioperative open lung ventilatory strategy in patients on one-lung ventilation (iPROVE-OLV).

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dc.contributor.authorCarramiñana, Albert
dc.contributor.authorFerrando, Carlos
dc.contributor.authorUnzueta, M. Carmen
dc.contributor.authorNavarro, Ricard
dc.contributor.authorSuárez-Sipmann, Fernando
dc.contributor.authorTusman, Gerardo
dc.contributor.authorGarutti, Ignacio
dc.contributor.authorSoro, Marina
dc.contributor.authorPozo, Natividad
dc.contributor.authorLibrero, Julián
dc.contributor.authorGallego, Lucía
dc.contributor.authorRamasco, Fernando
dc.contributor.authorRabanal, José M.
dc.contributor.authorRodriguez, Aurelio
dc.contributor.authorSastre, José
dc.contributor.authorMartinez, Jesús
dc.contributor.authorCoves, Silvia
dc.contributor.authorGarcía, Pablo
dc.contributor.authorAguirre-Puig, Pilar
dc.contributor.authorYepes, José
dc.contributor.authorLluch, Aitana
dc.contributor.authorLópez-Herrera, Daniel
dc.contributor.authorLeal, Sonsoles
dc.contributor.authorVives, Marc
dc.contributor.authorBellas, Soledad
dc.contributor.authorSocorro, Tania
dc.contributor.authorTrespalacios, Ramón
dc.contributor.authorSalazar, Claudia J.
dc.contributor.authorMugarra, Ana
dc.contributor.authorCinnella, Gilda
dc.contributor.authorSpadaro, Savino
dc.contributor.authorFutier, Emmanuel
dc.contributor.authorFerrer, Leopoldo
dc.contributor.authorCabrera, María
dc.contributor.authorRibeiro, Helder
dc.contributor.authorCelestino, Catarina
dc.contributor.authorKucur, Evrim
dc.contributor.authorCervantes, Oriol
dc.contributor.authorMorocho, Diego
dc.contributor.authorDelphy, Dalia
dc.contributor.authorRamos, Carolina
dc.contributor.authorVillar, Jesús
dc.contributor.authorBelda, Javier
dc.date.accessioned2020-05-14T20:47:13Z
dc.date.available2020-05-14T20:47:13Z
dc.date.issued2019
dc.description.abstractenglishObjective The aim of this clinical trial is to examine whether it is possible to reduce postoperative complications using an individualized perioperative ventilatory strategy versus using a standard lung-protective ventilation strategy in patients scheduled for thoracic surgery requiring one-lung ventilation. Design International, multicenter, prospective, randomized controlled clinical trial. Setting A network of university hospitals. Participants The study comprises 1,380 patients scheduled for thoracic surgery. Interventions The individualized group will receive intraoperative recruitment maneuvers followed by individualized positive end-expiratory pressure (open lung approach) during the intraoperative period plus postoperative ventilatory support with high-flow nasal cannula, whereas the control group will be managed with conventional lung-protective ventilation. Measurements and Main Results Individual and total number of postoperative complications, including atelectasis, pneumothorax, pleural effusion, pneumonia, acute lung injury; unplanned readmission and reintubation; length of stay and death in the critical care unit and in the hospital will be analyzed for both groups. The authors hypothesize that the intraoperative application of an open lung approach followed by an individual indication of high-flow nasal cannula in the postoperative period will reduce pulmonary complications and length of hospital stay in high-risk surgical patients.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1053/j.jvca.2019.01.056
dc.identifier.issn1053-0770
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2799
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalJournal of cardiothoracic and vascular anesthesiaspa
dc.relation.ispartofseriesJournal of cardiothoracic and vascular anesthesia, 1053-0770, Vol 33, Num 9, 2019, pag 2492-2502spa
dc.relation.urihttps://www.jcvaonline.com/article/S1053-0770(19)30092-8/fulltext
dc.rights.creativecommons2019
dc.rights.localAcceso cerradospa
dc.subject.decsPulmónspa
dc.subject.decsRespiraciónspa
dc.subject.decsCirugíaspa
dc.subject.keywordsMechanical ventilationspa
dc.subject.keywordsPostoperative pulmonary complicationsspa
dc.subject.keywordsOne-lung ventilationspa
dc.subject.keywordsPositive end-expiratory pressurespa
dc.subject.keywordsRecruitment maneuversspa
dc.titleRationale and study design for an individualized perioperative open lung ventilatory strategy in patients on one-lung ventilation (iPROVE-OLV).spa
dc.title.translatedRationale and study design for an individualized perioperative open lung ventilatory strategy in patients on one-lung ventilation (iPROVE-OLV).spa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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