Adjunctive clavulanic acid abolishes the cefazolin inoculum effect in an experimental rat model of methicillin-sensitive Staphylococcus aureus endocarditis

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Miller W.R., Singh K.V., Arias C.A., Murray B.E._2018.pdf (361.7 KB)

Fecha

2018

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Publicado en

Antimicrobial Agents and Chemotherapy, 1098-6596, Vol. 62, Nro. 11, 2018, p. 1-6

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American Society for Microbiology

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https://hdl.handle.net/20.500.12495/2698

URL de la fuente

https://aac.asm.org/content/62/11/e01158-18

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Abstract

We tested the ability of clavulanic acid to restore the efficacy of cefazolin against Staphylococcus aureus TX0117, which exhibits the cefazolin inoculum effect (CzIE). In the rat infective endocarditis model, the coadministration of cefazolin plus clavulanic acid resulted in a significant reduction of bacterial counts (7.1 ± 0.5 log10 CFU/g) compared to that with cefazolin alone (2 ± 0.6 log10 CFU/g; P < 0.0001). The addition of a β-lactamase inhibitor may be a viable strategy for overcoming the CzIE.

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Keywords

Staphylococcus aureus, Cefazolin, Animal models, Clavulanic acid

Temáticas

Endocarditis
Válvulas Cardíacas
Antibacterianos

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