Adjunctive clavulanic acid abolishes the cefazolin inoculum effect in an experimental rat model of methicillin-sensitive Staphylococcus aureus endocarditis

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dc.contributor.authorMiller, William R.
dc.contributor.authorSingh, Kavindra V.
dc.contributor.authorArias, Cesar A
dc.contributor.authorMurray, Barbara
dc.date.accessioned2020-05-13T19:17:04Z
dc.date.available2020-05-13T19:17:04Z
dc.date.issued2018
dc.description.abstractenglishWe tested the ability of clavulanic acid to restore the efficacy of cefazolin against Staphylococcus aureus TX0117, which exhibits the cefazolin inoculum effect (CzIE). In the rat infective endocarditis model, the coadministration of cefazolin plus clavulanic acid resulted in a significant reduction of bacterial counts (7.1 ± 0.5 log10 CFU/g) compared to that with cefazolin alone (2 ± 0.6 log10 CFU/g; P < 0.0001). The addition of a β-lactamase inhibitor may be a viable strategy for overcoming the CzIE.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1128/AAC.01158-18
dc.identifier.issn1098-6596
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2698
dc.language.isoeng
dc.publisherAmerican Society for Microbiologyspa
dc.publisher.journalAntimicrobial Agents and Chemotherapyspa
dc.relation.ispartofseriesAntimicrobial Agents and Chemotherapy, 1098-6596, Vol. 62, Nro. 11, 2018, p. 1-6spa
dc.relation.urihttps://aac.asm.org/content/62/11/e01158-18
dc.rights.creativecommons2018
dc.rights.localAcceso cerradospa
dc.subject.decsEndocarditisspa
dc.subject.decsVálvulas Cardíacasspa
dc.subject.decsAntibacterianosspa
dc.subject.keywordsStaphylococcus aureusspa
dc.subject.keywordsCefazolinspa
dc.subject.keywordsAnimal modelsspa
dc.subject.keywordsClavulanic acidspa
dc.titleAdjunctive clavulanic acid abolishes the cefazolin inoculum effect in an experimental rat model of methicillin-sensitive Staphylococcus aureus endocarditisspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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