Dengue virus infection of blood-brain barrier cells: consequences of severe disease

Vista sencilla de ítem
dc.contributor.authorCalderón-Peláez, María Angélica
dc.contributor.authorVelandia-Romero, Myriam Lucía
dc.contributor.authorBastidas Legarda, Leidy Y.
dc.contributor.authorBeltrán, Edgar O.
dc.contributor.authorCamacho Ortega, Sigrid Johanna
dc.contributor.authorCastellanos, Jaime
dc.contributor.orcidCastellanos, Jaime [0000-0003-1596-8383]
dc.contributor.orcidVelandia-Romero, Myriam Lucía [0000-0002-3340-7304]
dc.contributor.orcidCamacho Ortega, Sigrid Johanna [0000-0002-3145-4748]
dc.date.accessioned2019-09-16T17:54:41Z
dc.date.available2019-09-16T17:54:41Z
dc.date.issued2019
dc.description.abstractenglishMore than 500 million people worldwide are infected each year by any of the four-dengue virus (DENV) serotypes. The clinical spectrum caused during these infections is wide and some patients may develop neurological alterations during or after the infection, which could be explained by the cryptic neurotropic and neurovirulent features of flaviviruses like DENV. Using in vivo and in vitro models, researchers have demonstrated that DENV can affect the cells from the blood–brain barrier (BBB) in several ways, which could result in brain tissue damage, neuronal loss, glial activation, tissue inflammation and hemorrhages. The latter suggests that BBB may be compromised during infection; however, it is not clear whether the damage is due to the infection per se or to the local and/or systemic inflammatory response established or activated by the BBB cells. Similarly, the kinetics and cascade of events that trigger tissue damage, and the cells that initiate it, are unknown. This review presents evidence of the BBB cell infection with DENV and the response established toward it by these cells; it also describes the consequences of this response on the nervous tissue, compares these evidence with the one reported with neurotropic viruses of the Flaviviridae family, and shows the complexity and unpredictability of dengue and the neurological alterations induced by it. Clinical evidence and in vitro and in vivo models suggest that this virus uses the bloodstream to enter nerve tissue where it infects the different cells of the neurovascular unit. Each of the cell populations respond individually and collectively and control infection and inflammation, in other cases this response exacerbates the damage leaving irreversible sequelae or causing death. This information will allow us to understand more about the complex disease known as dengue, and its impact on a specialized and delicate tissue like is the nervous tissue.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://dx.doi.org/10.3389%2Ffmicb.2019.01435
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1664-302X
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1709
dc.language.isoeng
dc.publisherFrontiers Mediaspa
dc.publisher.journalFrontiers in Microbiologyspa
dc.relation.ispartofseriesFrontiers in Microbiology, 1664-302X, Vol.10, 2019 p. 1-15spa
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fmicb.2019.01435/full
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf52
dc.rights.creativecommons2019
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsInfecciones por Flaviviridaespa
dc.subject.decsVirus del denguespa
dc.subject.decsEnfermedades del sistema nerviosospa
dc.subject.keywordsBlood–brain barrier cellsspa
dc.subject.keywordsBreakdownspa
dc.subject.keywordsSevere denguespa
dc.titleDengue virus infection of blood-brain barrier cells: consequences of severe diseasespa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

Archivos

Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Calderón-Peláez M.-A., Velandia-Romero M.L., Bastidas-Legarda L.Y._2019.pdf
Tamaño:
453.94 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Artículos