Neutralizing antibodies from convalescent chikungunya virus patients can cross-neutralize mayaro and una viruses

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dc.contributor.authorMartins, Karen A.
dc.contributor.authorGregory, Melissa K.
dc.contributor.authorValdez, Stephanie M.
dc.contributor.authorSprague, Thomas R.
dc.contributor.authorEncinales, Liliana
dc.contributor.authorPacheco, Nelly
dc.contributor.authorCure, Carlos
dc.contributor.authorPorras-Ramírez, Alexandra
dc.contributor.authorRico-Mendoza, Alejandro
dc.contributor.authorChang, Aileen
dc.contributor.authorPitt, Margaret L.
dc.contributor.authorNasar, Farooq
dc.contributor.orcidPorras-Ramírez, Alexandra [0000-0002-0800-1388]
dc.date.accessioned2020-05-14T17:02:51Z
dc.date.available2020-05-14T17:02:51Z
dc.date.issued2019
dc.description.abstractenglishMost alphaviruses are mosquito-borne and can cause severe disease in domesticated animals and humans. The most notable recent outbreak in the Americas was the 2014 chikungunya virus (CHIKV) outbreak affecting millions and producing disease highlighted by rash and arthralgia. Chikungunya virus is a member of the Semliki Forest (SF) serocomplex, and before its arrival in the Americas, two other member of the SF complex, Una (UNAV) and Mayaro (MAYV) viruses, were circulating in Central and South America. This study examined whether antibodies from convalescent CHIKV patients could cross-neutralize UNAV and MAYV. Considerable cross-neutralization of both viruses was observed, suggesting that exposure to CHIKV can produce antibodies that may mitigate infection with UNAV or MAYV. Understanding the impact of CHIKV exposure on population susceptibility to other emerging viruses may help predict outbreaks; moreover, identification of cross-reactive immune responses among alphaviruses may lead to the development of vaccines targeting multiple viruses.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.4269/ajtmh.18-0756
dc.identifier.issn1476-1645
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2769
dc.language.isoeng
dc.publisherAmerican Society of Tropical Medicine and Hygienespa
dc.publisher.journalAmerican journal of tropical medicine and hygienespa
dc.relation.ispartofseriesAmerican journal of tropical medicine and hygiene, 1476-1645, Vol 100, Num 6, 2019, pag 1541-1544spa
dc.relation.urihttps://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0756
dc.rights.creativecommons2019
dc.rights.localAcceso cerradospa
dc.subject.decsAnticuerposspa
dc.subject.decsFlavivirusspa
dc.subject.decsVirusspa
dc.titleNeutralizing antibodies from convalescent chikungunya virus patients can cross-neutralize mayaro and una virusesspa
dc.title.translatedNeutralizing antibodies from convalescent chikungunya virus patients can cross-neutralize mayaro and una virusesspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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