Is the treatment with biological or non-biological DMARDS a modifier of periodontal condition in patients with rheumatoid arthritis?

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dc.contributor.authorRomero-Sánchez, Consuelo
dc.contributor.authorRodrígue, C.
dc.contributor.authorSantos-Moreno, P.
dc.contributor.authorMesa, A.
dc.contributor.authorLafaurie, Gloria Ines
dc.contributor.authorGiraldo-Q, S.
dc.contributor.authorDe-Avila, J.
dc.contributor.authorCastillo, DM.
dc.contributor.authorDuran, M.
dc.contributor.authorChalem Ch, P.
dc.contributor.authorBello Gualtero, JM.
dc.contributor.authorValle-Oñate, R.
dc.contributor.orcidLafaurie, Gloria Ines [0000-0003-3986-0625]
dc.contributor.orcidRomero-Sánchez, Consuelo [0000-0002-6973-7639]
dc.date.accessioned2020-08-04T14:05:08Z
dc.date.available2020-08-04T14:05:08Z
dc.description.abstractenglishBackground and objective: Experimental models suggest the use of different therapy protocols in rheumatoid arthritis (RA) as modulators on periodontal condition. This study evaluated the effects of conventional drug treatment and anti-TNF therapy in patients with RA on microbiological and periodontal condition, establishing the association of markers of periodontal infection with indexes of rheumatic activity. Materials and methods: One hundred seventy nine individuals with RA were evaluated (62 with anti-TNF-. and 115 with only DMARDs). The periodontal evaluation included plaque and gingival indexes, bleeding on probing (BOP), clinical attachment loss (CAL), pocket depth (PD) and subgingival plaque samples for microbiological analysis. Rheumatologic evaluations included a clinical examination, rheumatoid factor (RF), antibodies against cyclic-citrullinated peptides (ACPAs), and activity markers (DAS28-ERS), high sensitive C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR). Results: Anti-TNF-alpha therapy influenced periodontal microbiota with a higher frequency of T. denticola (p=0.01). Methotrexate combined with leflunomide exhibited a higher extension of CAL (p=0.005), and anti-TNF-alpha therapy with methotrexate was associated with a lower extension of CAL (p=0.05). The use of corticosteroids exerted a protective effect on the number of teeth (p=0.027). The type of DMARD affected P. gingivalis, T. forsythia and E. nodatum presence. Elevated ACPAs titers were associated with the presence of red complex periodontal pathogens (p=0.025). Bleeding on probing was associated with elevated CPR levels (p=0.05), and ESR was associated with a greater PD (p=0.044) and presence of red complex (p=0.030). Conclusion: Different pharmacological treatments for RA affect the clinical condition and subgingival microbiota.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.2174/1573397113666170407161520
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1875-6360
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3658
dc.language.isoeng
dc.publisherBenthamspa
dc.publisher.journalCurrent rheumatology reviewsspa
dc.relation.ispartofseriesCurrent Rheumatology Reviews, 1875-6360, 2017, Vol. 13, Nro. 2, p. 139-151spa
dc.relation.urihttps://www.eurekaselect.com/151449/article
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2017
dc.rights.localAcceso abiertospa
dc.subject.keywordsPeriodontal diseasespa
dc.subject.keywordsAntagonist tumor necrosis factor alpha (anti-TNF- alpha)spa
dc.subject.keywordsDiseasemodifying anti-rheumatic drug (DMARDs)spa
dc.subject.keywordsRheumatoid arthritisspa
dc.titleIs the treatment with biological or non-biological DMARDS a modifier of periodontal condition in patients with rheumatoid arthritis?spa
dc.title.translatedIs the treatment with biological or non-biological DMARDS a modifier of periodontal condition in patients with rheumatoid arthritis?spa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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