Association of adipokines with rheumatic disease activity indexes and periodontal disease in patients with early rheumatoid arthritis and their first‐degree relatives

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dc.contributor.authorChaparro Sanabria, Jeimy A.
dc.contributor.authorBautista-Molano, Wilson Armando
dc.contributor.authorBello Gualtero, Juan M.
dc.contributor.authorChila Moreno, Lorena
dc.contributor.authorCastillo, Diana M.
dc.contributor.authorValle Oñate, Rafael
dc.contributor.authorChalem, Phillipe
dc.contributor.authorRomero Sánchez, Consuelo
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.date.accessioned2020-03-26T22:28:41Z
dc.date.available2020-03-26T22:28:41Z
dc.date.issued2019
dc.description.abstractenglishObjective To evaluate the adipokine levels in early rheumatoid arthritis (eRA) and first‐degree relatives (FDR) of patients with RA and establish their association with rheumatic disease activity and periodontal variables. Method A cross‐sectional study with eRA patients, FDR and a healthy population. Adipokine levels, clinical, joint radiological indexes and periodontal variables were evaluated. A descriptive, bivariate analysis was performed based on the adipokine levels by χ2, Fisher's test and Mann–Whitney U test. A logistic regression was made for associations. Results High leptin levels were associated with the diagnosis of eRA (odds ratio [OR] = 2.79; 95% CI 1.54‐5.07). Early rheumatoid arthritis with high adiponectin levels was less likely to have Multidimensional Health Assessment Questionnaire score >3, body mass index (BMI) >25 and Routine Assessment of Patient Index Data 3 score >12 (OR = 0.16; 95% CI 0.03‐0.72). Early rheumatoid arthritis was more likely to present high leptin and interleukin (IL)6 levels with low adiponectin simultaneously (OR = 5.03; 95% CI 1.05‐24.0). High leptin levels were associated with the FDR adjusted for IgG2 Porphyromonas gingivalis, swollen joints, P gingivalis and low IL6 (OR = 2.57; 95% CI 1.14‐5.95). Conclusion High adipokine levels in eRA may modulate the disease activity. Having more than 1 adipokine at high serum levels is associated with increased disability, disease activity and BMI, indicating that RA is controlled by adiponectin levels in the early stages of the disease. High leptin levels, presence of P gingivalis and swollen joints may be the factors associated with the development of RA in FDR.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/1756-185X.13724
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1756-185X
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2159
dc.language.isoeng
dc.publisherWileyspa
dc.publisher.journalInternational Journal of Rheumatic Diseasesspa
dc.relation.ispartofseriesInternational Journal of Rheumatic Diseases, 1756-185X, Vol 22, Núm 11, 2019, pag 1990-2000spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.13724
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf92
dc.rights.creativecommons2019
dc.rights.localAcceso cerradospa
dc.subject.decsArtritis reumatoidespa
dc.subject.decsEnfermedades periodontalesspa
dc.subject.decsHormonas peptídicasspa
dc.subject.keywordsAdipokinesspa
dc.subject.keywordsAdiponectinspa
dc.subject.keywordsRheumatoid arthritisspa
dc.subject.keywordsLeptinspa
dc.subject.keywordsPeriodontitisspa
dc.titleAssociation of adipokines with rheumatic disease activity indexes and periodontal disease in patients with early rheumatoid arthritis and their first‐degree relativesspa
dc.title.translatedAssociation of adipokines with rheumatic disease activity indexes and periodontal disease in patients with early rheumatoid arthritis and their first‐degree relatives
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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