Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis

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dc.contributor.authorToro, Jaime
dc.contributor.authorReyes, Saúl
dc.contributor.authorDíaz-Cruz, Camilo
dc.contributor.authorBurbano, Lisseth Estefania
dc.contributor.authorCuellar-Giraldo, David
dc.contributor.authorDuque, Alejandra
dc.contributor.authorReyes-Mantilla, María I
dc.contributor.authorTorres, Camilo
dc.contributor.authorRíos, Jorge
dc.contributor.authorRivera Pérez, Juan Sebastián
dc.contributor.authorCortés-Muñoz, Fabián
dc.contributor.authorPatiño, Jorge
dc.contributor.authorNoriega, Daniel
dc.contributor.orcidToro, Jaime [0000-0001-7129-0058]
dc.contributor.orcidRivera Pérez, Juan Sebastián [0000-0002-7767-1289]
dc.contributor.orcidRivera Pérez, Juan Sebastián [0000-0002-7767-1289]
dc.date.accessioned2020-03-07T13:42:07Z
dc.date.available2020-03-07T13:42:07Z
dc.description.abstractenglishEpstein-Barr virus (EBV) seropositivity and smoking history in a Colombian population. Methods: We conducted a cross-sectional study between 2017 and 2018. We measured vitamin D levels and EBV antibody titers and administered a questionnaire to assess dietary habits, smoking, second-hand smoking and duration of smoking, sunlight exposure, physical activity, and personal and family history in individuals with and without multiple sclerosis during adolescence. A multivariable logistic regression model was then performed to explore the association between vitamin D status and MS. Results: : A total of 87 individuals with MS (mean age 40.9 years; 65.52% females) and 87 without MS (mean age 55 years; 65.52% females) were included in the analysis. In the multivariable analysis, after controlling for supplementation vitamin D levels did not differ between both groups and no difference was found regarding tobacco smoke exposure. The proportion of individuals who tested positive for anti-EBV nuclear antigen was significantly higher in individuals with MS (95.4% vs 82.76%, p = 0.028) Conclusion: We did not find a statistically significant association between MS and vitamin D levels while antiEBV nuclear antigen titers behaved as previously described in the literature. This study provides new evidence of the association between MS and different risk factors in our country, reinforcing the hypothesis that the pathogenesis of MS is multifactorial. Further studies are needed to better define the association between environmental factors and the development of MS in low prevalence areas.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.msard.2020.101983
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2211-0348
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2004
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalMultiple Sclerosis and Related Disordersspa
dc.relation.ispartofseriesMultiple Sclerosis and Related Disorders, 2211-0348, Vol. 41, 2020spa
dc.relation.urihttps://www.msard-journal.com/article/S2211-0348(20)30059-6/abstract
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf324
dc.rights.creativecommons2020
dc.rights.localAcceso cerradospa
dc.subject.decsFactores de riesgospa
dc.subject.decsEsclerosis múltiplespa
dc.subject.decsLuz Solarspa
dc.subject.keywordsEpstein-Barr virusspa
dc.subject.keywordsVitamin Dspa
dc.subject.keywordsSmokingspa
dc.titleVitamin D and other environmental risk factors in Colombian patients with multiple sclerosisspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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