Genomic analysis of ctx-m-group-1-producing extraintestinal pathogenic e. Coli (expec) from patients with urinary tract infections (uti) from colombia

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dc.contributor.authorde la Cadena, Elsa
dc.contributor.authorMojica, María Fernanda
dc.contributor.authorCastillo, Nathaly
dc.contributor.authorCorrea, Adriana M.
dc.contributor.authorAppel, Tobias Manuel
dc.contributor.authorGutiérrez Betancur, Juan Carlos
dc.contributor.authorPallares, Christian José
dc.contributor.authorVillegas, María Virginia
dc.contributor.orcidMojica, María Fernanda [0000-0002-1380-9824]
dc.contributor.orcidde la Cadena, Elsa [0000-0003-0361-7893]
dc.contributor.orcidPallares, Christian José [0000-0002-6093-7845]
dc.contributor.orcidVillegas, María Virginia [0000-0003-1898-9067]
dc.date.accessioned2021-01-28T16:05:40Z
dc.date.available2021-01-28T16:05:40Z
dc.description.abstractenglishBackground: The dissemination of the uropathogenic O25b-ST131Escherichia coliclone constitutes a threat to public health. We aimed to determine the circulation ofE. colistrains belonging to O25b:H4-B2-ST131 and theH30-Rx epidemic subclone causing hospital andcommunity-acquired urinary tract infections (UTI) in Colombia. Methods: Twenty-six nonduplicate,CTX-M group-1-producing isolates causing UTI in the hospital and community were selected for thisstudy. Results: Twenty-twoE. coliisolates harboring CTX-M-15, one CTX-M-3, and three CTX-M-55were identified. Multilocus Sequence Typing (MLST) showed a variety of sequence types (STs), amongwhich, ST131, ST405, and ST648 were reported as epidemic clones. All theE. coliST131 sequencescarried CTX-M-15, from which 80% belonged to the O25b:H4-B2 andH30-Rx pandemic subclonesand were associated with virulence factorsiss,iha, andsat.E. coliisolates (23/26) were resistant tociprofloxacin and associated with amino acid substitutions in quinolone resistance-determining regions(QRDR). We detected two carbapenem-resistantE. coliisolates, one coproducing CTX-M-15, KPC-2,and NDM-1 while the other presented mutations inompC. Additionally, one isolate harbored thegenemcr-1. Conclusions: Our study revealed the circulation of theE. coliST131, O25b:H4-B2-H30-Rxsubclone, harboring CTX-M-15, QRDR mutations, and other resistant genes. The association of theH30-Rx subclone with sepsis and rapid dissemination warrants attention from the public health andinfections control.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://dx.doi.org/10.3390/antibiotics9120899
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2019-6382
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5214
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)spa
dc.publisher.journalAntibioticsspa
dc.relation.ispartofseriesAntibiotics, 2019-6382, Vol. 9, Nro. 12, 2020, p. 1-9spa
dc.relation.urihttps://www.mdpi.com/2079-6382/9/12/899
dc.rightsAttribution 4.0 International*
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2020-12-13
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.keywordsE. coliST13spa
dc.subject.keywordsO25b:Hspa
dc.subject.keywordsH30-RX subclonspa
dc.subject.keywordsCTX-Mspa
dc.subject.keywordsurinary tract infections (UTI)spa
dc.subject.keywordsClonal disseminationspa
dc.titleGenomic analysis of ctx-m-group-1-producing extraintestinal pathogenic e. Coli (expec) from patients with urinary tract infections (uti) from colombiaspa
dc.title.translatedGenomic Analysis of CTX-M-Group-1-ProducingExtraintestinal PathogenicE. coli(ExPEc) fromPatients with Urinary Tract Infections (UTI)from Colombiaspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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