Adipokines and periodontal markers as risk indicators of early rheumatoid arthritis: a cross-sectional study

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dc.contributor.authorRodríguez, Jacqueline P.
dc.contributor.authorLafaurie, Gloria Ines
dc.contributor.authorBautista-Molano, Wilson Armando
dc.contributor.authorChila-Moreno, Lorena
dc.contributor.authorBello-Gualtero, Juan Manuel
dc.contributor.authorRomero-Sánchez, Consuelo
dc.contributor.orcidLafaurie, Gloria Ines [0000-0003-3986-0625]
dc.contributor.orcidRomero-Sánchez, Consuelo [0000-0002-6973-7639]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.date.accessioned2020-08-10T19:21:14Z
dc.date.available2020-08-10T19:21:14Z
dc.date.issued2020
dc.description.abstractenglishObjective: To establish the association between adipokine levels and markers of periodontal involvement as risk indicators of early stages of RA (eRA) and the interaction between the presence of markers of periodontal disease with adipokine in eRA individuals. Materials and methods: Fifty-one patients with a diagnosis of eRA and 51 healthy controls matched for age and sex were studied. Clinical joint condition, clinical and serological markers of disease activity, serum adipokine levels (leptin, adiponectin, resistin, adipsin, vaspin, and IL-6), periodontal diagnosis, presence of Porphyromonas gingivalis, and related IgG1 and IgG2 antibodies were evaluated. Comparisons were made between eRA and healthy controls for periodontal indicators and adipokines. A subgroup analysis was realized with a non-conditional logistic regression to establish the association between the levels of leptin in individuals with eRA and controls according to the periodontal condition, presence of P. gingivalis, or high titers of IgG antibodies against P. gingivalis. Results: The condition of overweight or obesity is associated with the diagnosis of eRA (p = 0.05), and these individuals also have higher levels of leptin (p = 0.001) and vaspin (p = 0.007). Higher frequency of P. gingivalis (p = 0.001) was found in the eRa group. Individuals with eRA with higher IgG2 titers against P. gingivalis had higher levels of leptin (OR: 1.66 (CI 95% 1.01–2.73)); however, individuals with periodontitis or P. gingivalis with eRA were associated with highest levels of leptin (OR: 1.86, CI 95% 1.19–24.3; and OR: 2.04, CI 95% 1.37–3 respectively). Conclusions: eRA individuals have high levels of leptin and vaspin. However, the presence of periodontitis and related-periodontal disease markers showed an effect only in leptin levels in eRA individuals. Clinical relevance: Emphasizing in personalized medicine, monitoring serum leptin levels and periodontitis markers can improve the early diagnosis of RA.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s00784-020-03469-0
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1436-3771
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3745
dc.language.isoeng
dc.publisherSpringer Naturespa
dc.publisher.journalClinical oral investigationsspa
dc.relation.ispartofseriesClinical oral investigations, 1436-3771, 2020spa
dc.relation.urihttps://link.springer.com/article/10.1007%2Fs00784-020-03469-0
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2020-08-01
dc.rights.localAcceso abiertospa
dc.subject.keywordsAdipokinesspa
dc.subject.keywordsPeriodontitisspa
dc.subject.keywordsRheumatoidspa
dc.subject.keywordsArthritisspa
dc.subject.keywordsPorphyromonas gingivalisspa
dc.titleAdipokines and periodontal markers as risk indicators of early rheumatoid arthritis: a cross-sectional studyspa
dc.title.translatedAdipokines and periodontal markers as risk indicators of early rheumatoid arthritis: a cross-sectional studyspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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