Manifestaciones neurologicas de la iInfección congenita por citomegalovirus, revision sistematica de literatura

Sanchez Herrera, Natalia

Manifestaciones neurologicas de la iInfección congenita por citomegalovirus, revision sistematica de literatura

dc.contributor.advisor	Baez Camacho, Martha
dc.contributor.advisor	Peña Hoyos, Eliana
dc.contributor.author	Sanchez Herrera, Natalia
dc.contributor.orcid	Sanchez Herrera, Natalia [009-0002-6093-4916]
dc.date.accessioned	2024-08-02T19:23:35Z
dc.date.available	2024-08-02T19:23:35Z
dc.date.issued	2024-07
dc.description.abstract	Las malformaciones o defectos congénitos suelen producirse durante la vida intrauterina. Estas pueden ser fácilmente identificables (1–3) o pasar desapercibidas, y por lo tanto requerir el uso de paraclínicos específicos para detectar su presencia (2). Es por ello que las condiciones de salud materna durante la gestación y en torno al nacimiento son trascendentales para el curso de la vida de los niños afectados (3). Describir las manifestaciones neurológicas secundarias a infección congénita por Citomegalovirus (CMV) en pacientes menores de 5 años. Revisión de la literatura tipo Scoping review. Se consultaron las bases de datos PUBMED, EMBASE, ELSEVIER, SPRINGER, OVID, para el periodo comprendido entre 2010 y 2024, artículos que evaluaran las manifestaciones neurológicas secundarias a la infección congénita por Citomegalovirus (CMV). La revisión de la literatura muestra que la infección congénita por citomegalovirus (cCMV) tiene una prevalencia del 0.67% en recién nacidos, siendo tres veces mayor en países de ingresos bajos y medianos. Las manifestaciones neurológicas, que incluyen microcefalia, convulsiones y déficits motores, afectan al 65% de los pacientes con cCMV. Además, la hipoacusia neurosensorial se presenta en un 8% a 32% de los casos, con una prevalencia más alta en recién nacidos sintomáticos. La relación entre el momento de la infección durante el embarazo y la gravedad de las manifestaciones neurológicas resalta la importancia de la detección y prevención tempranas. Las imágenes cerebrales revelan hallazgos críticos como calcificaciones intracraneales y ventriculomegalia, indicadores de posibles secuelas neurológicas. Los biomarcadores plasmáticos como FLT4 y PPIA emergen como herramientas prometedoras para el diagnóstico de complicaciones neurológicas. El tamizaje neonatal y la intervención temprana son esenciales para mejorar los resultados en niños afectados por cCMV.
dc.description.abstractenglish	Congenital malformations or defects usually occur during intrauterine life. These can be easily identifiable (1-3) or go unnoticed, and therefore require the use of specific paraclinicals to detect their presence (2). That is why maternal health conditions during gestation and around birth are transcendental for the life course of affected children (3). Objective. To describe the neurological manifestations secondary to congenital Cytomegalovirus (CMV) infection in patients under 5 years of age. Materials and methods. Scoping review. PUBMED/MEDLINE, LILACS, COCHRANE library, Scopus, EMBASE and Google Scholar databases were consulted for the period between 2010-2024, articles evaluating neurological manifestations secondary to congenital Cytomegalovirus (CMV) infection. A review of the literature shows that congenital cytomegalovirus (cCMV) infection has a prevalence of 0.67% in newborns, being three times higher in low- and middle-income countries. Neurological manifestations, including microcephaly, seizures, and motor deficits, affect 65% of patients with cCMV. Additionally, sensorineural hearing loss occurs in 8% to 32% of cases, with a higher prevalence in symptomatic newborns. The relationship between the timing of infection during pregnancy and the severity of neurological manifestations highlights the importance of early detection and prevention. Brain imaging reveals critical findings such as intracranial calcifications and ventriculomegaly, indicators of potential neurological sequelae. Plasma biomarkers like FLT4 and PPIA emerge as promising tools for diagnosing neurological complications. Education, neonatal screening, and early intervention are essential to improve outcomes in children affected by cCMV.
dc.description.degreelevel	Especialización	spa
dc.description.degreename	Especialista en Pediatría	spa
dc.format.mimetype	application/pdf
dc.identifier.instname	instname:Universidad El Bosque	spa
dc.identifier.reponame	reponame:Repositorio Institucional Universidad El Bosque	spa
dc.identifier.repourl	repourl:https://repositorio.unbosque.edu.co
dc.identifier.uri	https://hdl.handle.net/20.500.12495/12808
dc.language.iso	es
dc.publisher.faculty	Facultad de Medicina	spa
dc.publisher.grantor	Universidad El Bosque	spa
dc.publisher.program	Especialización en Pediatría	spa
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dc.rights	Atribución-NoComercial-CompartirIgual 4.0 Internacional	en
dc.rights.accessrights	info:eu-repo/semantics/openAccess
dc.rights.accessrights	info:eu-repo/semantics/openAccess
dc.rights.local	Acceso abierto	spa
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject	Embarazada
dc.subject	Neonato
dc.subject	Niño
dc.subject	Recién nacido
dc.subject	Citomegalovirus
dc.subject	Herpesvirus Humano 5
dc.subject	Infección congénita
dc.subject	Infección citomegalovirus
dc.subject	Anomalías fetales
dc.subject	Defectos de nacimiento
dc.subject	Trastornos del Neurodesarrollo
dc.subject	Anormalidades congénitas
dc.subject	Malformación sistema nervioso
dc.subject.keywords	Pregnant Woman
dc.subject.keywords	Neonate
dc.subject.keywords	Child
dc.subject.keywords	Newborn Infant
dc.subject.keywords	Cytomegalovirus
dc.subject.keywords	Human Herpesvirus 5
dc.subject.keywords	Congenital infection
dc.subject.keywords	Cytomegalovirus infection
dc.subject.keywords	Congenital Abnormalities,
dc.subject.keywords	Anomalies Birth defects
dc.subject.keywords	Neurodevelopmental Disorders
dc.subject.keywords	Congenital abnormalities
dc.subject.keywords	Malformations Nervous System
dc.subject.nlm	WS 100
dc.title	Manifestaciones neurologicas de la iInfección congenita por citomegalovirus, revision sistematica de literatura
dc.title.translated	Neurological manifestations of congenital cytomegalovirus infection, a systematic literature review
dc.type.coar	https://purl.org/coar/resource_type/c_7a1f
dc.type.coarversion	https://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driver	info:eu-repo/semantics/bachelorThesis
dc.type.hasversion	info:eu-repo/semantics/acceptedVersion
dc.type.local	Tesis/Trabajo de grado - Monografía - Especialización	spa