Gastrointestinal symptoms and elevated levels of anti- saccharomyces cerevisiae antibodies are associated with higher disease activity in Colombian patients with spondyloarthritis

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dc.contributor.authorRomero-Sánchez, Consuelo
dc.contributor.authorParra, Viviana
dc.contributor.authorDe Avila, Juliette
dc.contributor.authorRueda, Juan Camilo
dc.contributor.authorLondoño, John Darío
dc.contributor.authorValle-Oñate, Rafael
dc.contributor.authorBautista-Molano, Wilson Armando
dc.contributor.authorBello-Gualtero, Juan M.
dc.contributor.orcidRomero-Sánchez, Consuelo [0000-0002-6973-7639]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.date.accessioned2019-08-26T17:17:03Z
dc.date.available2019-08-26T17:17:03Z
dc.date.issued2017
dc.description.abstractenglishBackground. Spondyloarthritis (SpA) is a group of articular inflammatory rheumatic diseases that their gastrointestinal manifestations are around 10% of their extra-articular symptoms, supporting that the inflammatory response of the intestinal mucosa could be associated with the clinical status. Objectives. To investigate the association between gastrointestinal symptoms and autoantibodies and disease activity between SpA patients, healthy subjects (HS), and patients with inflammatory bowel disease (IBD). Methods. 102 SpA patients, 29 IBD patients, and 117 HS were included. Autoantibodies as ASCA, ANCA, anti-tTG, anti-DGP, ANA, and IgA were measured. The patients were assessed to evaluate clinical and gastrointestinal symptoms. An association analysis was performed using Chi square test and a logistic regression. Results. Significant ifferences were found for ASCA levels in SpA (28.2%) compared to IBD (14.2%) and HS (6.0%) (p = 0.029), as well as for ANAS in SpA (49.5%) and IBD (37.9%) (p < 0.001) and abdominal pain (p = 0.012) between SpA (54.3%) and IBD (27.5%). Significant associations were found between ASDAI > 4 and gastrointestinal symptoms (p < 0.05) and IgA (p = 0.007). The association for abdominal bloating was maintained (OR: 3.93, CI-95%, 1.14–13.56; p = 0.030). Conclusions. Gastrointestinal symptoms, ASCA, ANAS, and IgA levels were associated with high disease activity in SpA compared with IBD and HS.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1155/2017/4029584
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1687-9260
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1647
dc.language.isoeng
dc.publisherHindawi Publishing Corporationspa
dc.publisher.journalInternational Journal of Rheumatologyspa
dc.relation.ispartofseriesInternational Journal of Rheumatology, 1687-9260, 2017, p.1- 8spa
dc.relation.urihttps://www.hindawi.com/journals/ijr/2017/4029584/
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf301
dc.rights.creativecommons2017
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsMucosa intestinalspa
dc.subject.decsEnfermedades reumáticasspa
dc.subject.decsEspondiloartritisspa
dc.titleGastrointestinal symptoms and elevated levels of anti- saccharomyces cerevisiae antibodies are associated with higher disease activity in Colombian patients with spondyloarthritisspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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Romero-Sánchez C., Bautista-Molano W., Parra V., De Avila J., Rueda J.C., Bello-Gualtero J.M., Londoño J., Valle-Oñate R._2017.pdf
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