Parallel epidemics of community-associated methicillin-resistant staphylococcus aureus USA300 infection in north and south america

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dc.contributor.authorPlanet, Paul J.
dc.contributor.authorDiaz, Lorena
dc.contributor.authorKolokotronis, Sergios-Orestis
dc.contributor.authorNarechania, Apurva
dc.contributor.authorReyes, Jinnethe
dc.contributor.authorXing, Galen
dc.contributor.authorRincon Núñez, Sandra
dc.contributor.authorSmith, Hannah
dc.contributor.authorPanesso, Diana
dc.contributor.authorRyan, Chanelle
dc.contributor.authorSmith, Dylan P.
dc.contributor.authorGuzman, Manuel
dc.contributor.authorZurita, Jeannete
dc.contributor.authorSebra, Robert
dc.contributor.authorDeikus, Gintaras
dc.contributor.authorNolan, Rathel L.
dc.contributor.authorTenover, Fred C.
dc.contributor.authorWeinstock, George M.
dc.contributor.authorRobinson, D. Ashley
dc.contributor.authorArias, Cesar A.
dc.contributor.orcidPanesso, Diana [0000-0002-4049-9702]
dc.contributor.orcidRincon Núñez, Sandra [0000-0002-8482-4554]
dc.date.accessioned2020-08-12T20:05:10Z
dc.date.available2020-08-12T20:05:10Z
dc.date.issued2015
dc.description.abstractenglishBackground. The community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) epidemic in the United States is attributed to the spread of the USA300 clone. An epidemic of CA-MRSA closely related to USA300 has occurred in northern South America (USA300 Latin-American variant, USA300-LV). Using phylogenomic analysis, we aimed to understand the relationships between these 2 epidemics. Methods. We sequenced the genomes of 51 MRSA clinical isolates collected between 1999 and 2012 from the United States, Colombia, Venezuela, and Ecuador. Phylogenetic analysis was used to infer the relationships and times since the divergence of the major clades. Results. Phylogenetic analyses revealed 2 dominant clades that segregated by geographical region, had a putative common ancestor in 1975, and originated in 1989, in North America, and in 1985, in South America. Emergence of these parallel epidemics coincides with the independent acquisition of the arginine catabolic mobile element (ACME) in North American isolates and a novel copper and mercury resistance (COMER) mobile element in South American isolates. Conclusions. Our results reveal the existence of 2 parallel USA300 epidemics that shared a recent common ancestor. The simultaneous rapid dissemination of these 2 epidemic clades suggests the presence of shared, potentially convergent adaptations that enhance fitness and ability to spread.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1093/infdis/jiv320
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1537-6613
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3771
dc.language.isoeng
dc.publisherOxford University Pressspa
dc.publisher.journalJournal of Infectious Diseasesspa
dc.relation.ispartofseriesJournal of Infectious Diseases, 1537-6613, Vol. 212, Nro. 12, 2015, p. 1874–1882spa
dc.relation.urihttps://academic.oup.com/jid/article/212/12/1874/2911927
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2015-06-05
dc.rights.localAcceso abiertospa
dc.subject.keywordsUSA300spa
dc.subject.keywordsUSA300-LVspa
dc.subject.keywordsMRSAspa
dc.subject.keywordsEpidemicsspa
dc.titleParallel epidemics of community-associated methicillin-resistant staphylococcus aureus USA300 infection in north and south americaspa
dc.title.translatedParallel epidemics of community-associated methicillin-resistant staphylococcus aureus USA300 infection in north and south americaspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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