Characterization of cytomegalovirus lung infection in Non-HIV infected children

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dc.contributor.authorRestrepo-Gualteros, Sonia M.
dc.contributor.authorJaramillo-Barberi, Lina E.
dc.contributor.authorGonzalez-Santos, Monica
dc.contributor.authorPerez, Geovanny F.
dc.contributor.authorGutierrez, Maria J.
dc.contributor.authorNino, Gustavo
dc.contributor.authorRodríguez-Martínez, Carlos E.
dc.date.accessioned2019-09-24T18:58:27Z
dc.date.available2019-09-24T18:58:27Z
dc.date.issued2014
dc.description.abstractenglishCytomegalovirus (CMV) is a prevalent pathogen in the immunocompromised host and invasive pneumonia is a feared complication of the virus in this population. In this pediatric case series we characterized CMV lung infection in 15 non-HIV infected children (median age 3 years; IQR 0.2–4.9 years), using current molecular and imaging diagnostic modalities, in combination with respiratory signs and symptoms. The most prominent clinical and laboratory findings included cough (100%), hypoxemia (100%), diffuse adventitious breath sounds (100%) and increased respiratory effort (93%). All patients had abnormal lung images characterized by ground glass opacity/consolidation in 80% of cases. CMV was detected in the lung either by CMV PCR in bronchoalveolar lavage (82% detection rate) or histology/immunohistochemistry in lung biopsy (100% detection rate). CMV caused respiratory failure in 47% of children infected and the overall mortality rate was 13.3%. Conclusion: CMV pneumonia is a potential lethal disease in non-HIV infected children that requires a high-index of suspicion. Common clinical and radiological patterns such as hypoxemia, diffuse adventitious lung sounds and ground-glass pulmonary opacities may allow early identification of CMV lung infection in the pediatric population, which may lead to prompt initiation of antiviral therapy and better clinical outcomes.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/v6052038
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1999-4915
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1742
dc.language.isoeng
dc.publisherMDPIspa
dc.publisher.journalVirusesspa
dc.relation.ispartofseriesViruses, 1999-4915, Vol. 6,Nro.5 2014, p.2038-2051spa
dc.relation.urihttps://www.mdpi.com/1999-4915/6/5/2038
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf277
dc.rights.creativecommons2014
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsNeumoníaspa
dc.subject.decsInfecciones por citomegalovirusspa
dc.subject.decsSíndromes de inmunodeficienciaspa
dc.subject.keywordsCMVspa
dc.subject.keywordsLungspa
dc.subject.keywordsPneumoniaspa
dc.subject.keywordsChildrenspa
dc.subject.keywordsGround glassspa
dc.titleCharacterization of cytomegalovirus lung infection in Non-HIV infected childrenspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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Restrepo-Gualteros S.M., Jaramillo-Barberi L.E., Gonzalez-Santos M., Rodriguez-Martinez C.E., Perez G.F., Gutierrez M.J., Nino G._2014.pdf
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