Development of a Model of Pediatric Lung Failure Pathophysiology

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dc.contributor.authorTrahanas, John M.
dc.contributor.authorAlghanem, Fares
dc.contributor.authorCeballos-Muriel, Catalina
dc.contributor.authorHoffman, Hayley R.
dc.contributor.authorXu, Alice
dc.contributor.authorDeatrick, Kristopher Barry
dc.contributor.authorCornell, Marie S.
dc.contributor.authorRojas-Pena, Alvaro
dc.contributor.authorBartlett, Robert H.
dc.date.accessioned2020-07-10T17:25:00Z
dc.date.available2020-07-10T17:25:00Z
dc.description.abstractenglishA pediatric artificial lung (PAL) is under development as a bridge to transplantation or lung remodeling for children with end-stage lung failure (ESLF). To evaluate the efficiency of a PAL, a disease model mimicking the physiologic derangements of pediatric ESLF is needed. Our previous right pulmonary artery (rPA) ligation model (rPA-LM) achieved that goal, but caused immediate mortality in nearly half of the animals. In this study, we evaluated a new technique of gradual postoperative right pulmonary artery occlusion using a Rummel tourniquet (rPA-RT) in seven (25–40 kg) sheep. This technique created a stable model of ESLF pathophysiology, characterized by high alveolar dead space (58.0% ± 3.8%), pulmonary hypertension (38.4 ± 2.2 mm Hg), tachypnea (79 ± 20 breaths per minute), and intermittent supplemental oxygen requirement. This improvement to our technique provides the necessary physiologic derangements for testing a PAL, whereas avoiding the problem of high immediate perioperative mortality.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1097/mat.0000000000000463
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1538-943X
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3436
dc.language.isoeng
dc.publisherWolters Kluwer Healthspa
dc.publisher.journalASAIO Journalspa
dc.relation.ispartofseriesASAIO Journal, 1538-943X, Vol. 63, Nro. 2, 2017, p. 216-222spa
dc.relation.urihttps://journals.lww.com/asaiojournal/Fulltext/2017/03000/Development_of_a_Model_of_Pediatric_Lung_Failure.18.aspx
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2017-04
dc.rights.localAcceso abiertospa
dc.subject.decsPrótesis e implantesspa
dc.subject.decsMortalidad del niñospa
dc.subject.decstrasplante de pulmónspa
dc.subject.keywordslung failurespa
dc.subject.keywordsAnimal modespa
dc.subject.keywordsPulmonary hypertensionspa
dc.titleDevelopment of a Model of Pediatric Lung Failure Pathophysiologyspa
dc.title.translatedDevelopment of a Model of Pediatric Lung Failure Pathophysiologyspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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