Development of a Model of Pediatric Lung Failure Pathophysiology
dc.contributor.author | Trahanas, John M. | |
dc.contributor.author | Alghanem, Fares | |
dc.contributor.author | Ceballos-Muriel, Catalina | |
dc.contributor.author | Hoffman, Hayley R. | |
dc.contributor.author | Xu, Alice | |
dc.contributor.author | Deatrick, Kristopher Barry | |
dc.contributor.author | Cornell, Marie S. | |
dc.contributor.author | Rojas-Pena, Alvaro | |
dc.contributor.author | Bartlett, Robert H. | |
dc.date.accessioned | 2020-07-10T17:25:00Z | |
dc.date.available | 2020-07-10T17:25:00Z | |
dc.description.abstractenglish | A pediatric artificial lung (PAL) is under development as a bridge to transplantation or lung remodeling for children with end-stage lung failure (ESLF). To evaluate the efficiency of a PAL, a disease model mimicking the physiologic derangements of pediatric ESLF is needed. Our previous right pulmonary artery (rPA) ligation model (rPA-LM) achieved that goal, but caused immediate mortality in nearly half of the animals. In this study, we evaluated a new technique of gradual postoperative right pulmonary artery occlusion using a Rummel tourniquet (rPA-RT) in seven (25–40 kg) sheep. This technique created a stable model of ESLF pathophysiology, characterized by high alveolar dead space (58.0% ± 3.8%), pulmonary hypertension (38.4 ± 2.2 mm Hg), tachypnea (79 ± 20 breaths per minute), and intermittent supplemental oxygen requirement. This improvement to our technique provides the necessary physiologic derangements for testing a PAL, whereas avoiding the problem of high immediate perioperative mortality. | eng |
dc.format.mimetype | application/pdf | |
dc.identifier.doi | https://doi.org/10.1097/mat.0000000000000463 | |
dc.identifier.instname | instname:Universidad El Bosque | spa |
dc.identifier.issn | 1538-943X | |
dc.identifier.reponame | reponame:Repositorio Institucional Universidad El Bosque | spa |
dc.identifier.repourl | https://repositorio.unbosque.edu.co | |
dc.identifier.uri | https://hdl.handle.net/20.500.12495/3436 | |
dc.language.iso | eng | |
dc.publisher | Wolters Kluwer Health | spa |
dc.publisher.journal | ASAIO Journal | spa |
dc.relation.ispartofseries | ASAIO Journal, 1538-943X, Vol. 63, Nro. 2, 2017, p. 216-222 | spa |
dc.relation.uri | https://journals.lww.com/asaiojournal/Fulltext/2017/03000/Development_of_a_Model_of_Pediatric_Lung_Failure.18.aspx | |
dc.rights.accessrights | https://purl.org/coar/access_right/c_abf2 | |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | |
dc.rights.accessrights | Acceso abierto | |
dc.rights.creativecommons | 2017-04 | |
dc.rights.local | Acceso abierto | spa |
dc.subject.decs | Prótesis e implantes | spa |
dc.subject.decs | Mortalidad del niño | spa |
dc.subject.decs | trasplante de pulmón | spa |
dc.subject.keywords | lung failure | spa |
dc.subject.keywords | Animal mode | spa |
dc.subject.keywords | Pulmonary hypertension | spa |
dc.title | Development of a Model of Pediatric Lung Failure Pathophysiology | spa |
dc.title.translated | Development of a Model of Pediatric Lung Failure Pathophysiology | spa |
dc.type.coar | https://purl.org/coar/resource_type/c_6501 | |
dc.type.driver | info:eu-repo/semantics/article | |
dc.type.hasversion | info:eu-repo/semantics/publishedVersion | |
dc.type.local | Artículo de revista |
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