First report and comparative genomics analysis of a blaoxa-244-haarboring escherichia coli isolate recovered in the American continent

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dc.contributor.authorAbril Riaño, Deisy Julieth
dc.contributor.authorBustos Moya, Ingrid Gisell
dc.contributor.authorMárquez-Ortiz, Ricaurte Alejandro
dc.contributor.authorJosa, Diego
dc.contributor.authorCorredor Rozo, Zayda Lorena
dc.contributor.authorTorres Molina, Isabel
dc.contributor.authorVanegas Gómez, Natasha
dc.contributor.authorEscobar-Pérez, Javier
dc.contributor.orcidEscobar-Pérez, Javier [0000-0002-0432-6978]
dc.contributor.orcidAbril Riaño, Deisy Julieth [0000-0002-6686-6283]
dc.date.accessioned2020-03-24T15:06:32Z
dc.date.available2020-03-24T15:06:32Z
dc.date.issued2019
dc.description.abstractenglishThe carbapenemase OXA-244 is a derivate of OXA-48, and its detection is very difficult in laboratories. Here, we report the identification and genomic analysis of an Escherichia coli isolate (28Eco12) harboring the blaOXA-244 gene identified in Colombia, South America. The 28Eco12 isolate was identified during a retrospective study, and it was recovered from a patient treated in Colombia. The complete nucleotide sequence was established using the PacBio platform. A comparative genomics analysis with other blaOXA-244–harboring Escherichia coli strains was performed. The 28Eco12 isolate belonged to sequence type (ST) 38, and its genome was composed of two molecules, a chromosome of 5,343,367 bp and a plasmid of 92,027 bp, which belonged to the incompatibility group IncY and did not harbor resistance genes. The blaOXA-244 gene was chromosomally encoded and mobilized by an ISR1-related Tn6237 composite transposon. Notably, this transposon was inserted and located within a new genomic island. To our knowledge, this is the first report of a blaOXA-244–harboring Escherichia coli isolate in America. Our results suggest that the introduction of the OXA-244-producing E. coli isolate was through clonal expansion of the ST38 pandemic clone. Other isolates producing OXA-244 could be circulating silently in America.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/antibiotics8040222
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2079-6382
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2088
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalAntibioticsspa
dc.relation.ispartofseriesAntibiotics, 2079-6382, Vol. 8, Nro. 4, 2019, p. 2-9spa
dc.relation.urihttps://www.mdpi.com/2079-6382/8/4/222
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.creativecommons2019
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsCódigo genéticospa
dc.subject.decsInformes de casosspa
dc.subject.decsEnterobacteriaceaespa
dc.subject.keywordsCarbapenemsspa
dc.subject.keywordsResistancespa
dc.subject.keywordsBlaOXA-244spa
dc.titleFirst report and comparative genomics analysis of a blaoxa-244-haarboring escherichia coli isolate recovered in the American continentspa
dc.title.translatedFirst report and comparative genomics analysis of a blaoxa-244-haarboring escherichia coli isolate recovered in the American continent
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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Abril D., Moya I.G.B., Marquez-Ortiz R.A., Montero D.F.J., Rozo Z.L.C., Molina I.T., Gómez N.V., Escobar-Perez J.,_2019.pdf
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