A prospective cohort multicenter study of molecular epidemiology and phylogenomics of Staphylococcus aureus bacteremia in nine Latin American countries

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dc.contributor.authorArias, Cesar A.
dc.contributor.authorReyes, Jinnethe
dc.contributor.authorCarvajal Ortiz, Lina Paola
dc.contributor.authorRincon Núñez, Sandra
dc.contributor.authorDiaz, Lorena
dc.contributor.authorPanesso, Diana
dc.contributor.authorIbarra, Gabriel
dc.contributor.authorRios, Rafael
dc.contributor.authorMunita, Jose M.
dc.contributor.authorAlvarez-Moreno, Carlos
dc.contributor.authorLabarca, Jaime
dc.contributor.authorGarcia, Coralith
dc.contributor.authorLuna, Carlos M.
dc.contributor.authorMejia-Villatoro, Carlos
dc.contributor.authorZurita, Jeannete
dc.contributor.authorGuzman-Blanco, Manuel
dc.contributor.authorRodriguez-Noriega, Eduardo
dc.contributor.authorNarechania, Apurva
dc.contributor.authorRojas, Laura J.
dc.contributor.authorPlanet, Paul J.
dc.contributor.authorWeinstock, George M.
dc.contributor.authorGotuzzo, Eduardo
dc.contributor.authorSeas, Carlos
dc.contributor.orcidPanesso, Diana [0000-0002-4049-9702]
dc.contributor.orcidRincon Núñez, Sandra [0000-0002-8482-4554]
dc.contributor.orcidCarvajal Ortiz, Lina Paola [0000-0001-8301-8836]
dc.date.accessioned2021-02-08T18:53:39Z
dc.date.available2021-02-08T18:53:39Z
dc.description.abstractenglishStaphylococcus aureus is an important pathogen causing a spectrum of diseases ranging from mild skin and soft tissue infections to life-threatening conditions. Bloodstream infections are particularly important, and the treatment approach is complicated by the presence of methicillin-resistant S. aureus (MRSA) isolates. The emergence of new genetic lineages of MRSA has occurred in Latin America (LA) with the rise and dissemination of the community-associated USA300 Latin American variant (USA300-LV). Here, we prospectively characterized bloodstream MRSA recovered from selected hospitals in 9 Latin American countries. All isolates were typed by pulsed-field gel electrophoresis (PFGE) and subjected to antibiotic susceptibility testing. Whole-genome sequencing was performed on 96 MRSA representatives. MRSA represented 45% of all (1,185 S. aureus) isolates. The majority of MRSA isolates belonged to clonal cluster (CC) 5. In Colombia and Ecuador, most isolates (≥72%) belonged to the USA300-LV lineage (CC8). Phylogenetic reconstructions indicated that MRSA isolates from participating hospitals belonged to three major clades. Clade A grouped isolates with sequence type 5 (ST5), ST105, and ST1011 (mostly staphylococcal chromosomal cassette mec [SCCmec] I and II). Clade B included ST8, ST88, ST97, and ST72 strains (SCCmec IV, subtypes a, b, and c/E), and clade C grouped mostly Argentinian MRSA belonging to ST30. In summary, CC5 MRSA was prevalent in bloodstream infections in LA with the exception of Colombia and Ecuador, where USA300-LV is now the dominant lineage. Clonal replacement appears to be a common phenomenon, and continuous surveillance is crucial to identify changes in the molecular epidemiology of MRSA.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1128/aac.00816-17
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1098-6596
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5262
dc.language.isoeng
dc.publisherAmerican Society for Microbiologyspa
dc.publisher.journalAntimicrobial Agents and Chemotherapyspa
dc.relation.ispartofseriesAntimicrobial Agents and Chemotherapy, 1098-6596, Vol. 61, No. 10, 2017, p. 145-152spa
dc.relation.urihttps://aac.asm.org/content/61/10/e00816-17.long
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2017
dc.rights.localAcceso cerradospa
dc.subject.keywordsLatin Americaspa
dc.subject.keywordsStaphylococcus aureusspa
dc.subject.keywordsBacteremiaspa
dc.titleA prospective cohort multicenter study of molecular epidemiology and phylogenomics of Staphylococcus aureus bacteremia in nine Latin American countriesspa
dc.title.translatedA prospective cohort multicenter study of molecular epidemiology and phylogenomics of Staphylococcus aureus bacteremia in nine Latin American countriesspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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