Increased tissue factor and thrombomodulin expression and histopathological changes in placentas of pregnancies with preeclampsia

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dc.contributor.authorAyala-Ramírez, P.
dc.contributor.authorBuitrago, T.
dc.contributor.authorPoveda, A.
dc.contributor.authorRodríguez, J L.
dc.contributor.authorOlaya-C, M.
dc.contributor.authorGarcía-Robles, R.
dc.date.accessioned2020-07-31T15:12:21Z
dc.date.available2020-07-31T15:12:21Z
dc.description.abstractenglishAbstract Introduction: Preeclampsia has a global frequency of 2-8% and a frequency of 10% in developing countries. In Colombia, preeclampsia causes 42% of maternal mortality. Alterations in placental homeostasis have been proposed to be involved in its pathophysiology. The aim of this study was to compare mRNA and protein levels of tissue factor (F3) and thrombomodulin (THBD) and the histopathological findings of placentas. Materials and methods: We studied 16 placentas from patients with preeclampsia and 19 term placentas with uncomplicated pregnancy. An expert pathologist, who was masked to the group assignment, conducted an evaluation to determine specific histological changes. Assessments of mRNA and protein levels of F3 and THBD were performed using real-time PCR and ELISA, respectively. Results: Cases and controls differed in the frequency of decidual arteriopathy (p = 0.027), acute infarction (p = 0.001) and hyperplasia of the syncytiotrophoblast (p = 0.0017). Cases had increased levels of F3 mRNA (p = 0.0124) and protein (p < 0.0001) and THBD mRNA (p < 0.0001) and protein (p < 0.0001). Conclusion: In placenta of patients with preeclampsia, we detected abnormal expression of F3 and THBD with increased protein and mRNA levels. The role of these molecules in the pathogenesis of this disease and in alterations of hemostatic and histopathological aspects of placentas need further studying.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3233/NPM-16915034
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1878-4429
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3633
dc.language.isoeng
dc.publisherIOS Pressspa
dc.publisher.journalJournal of neonatal-perinatal medicinespa
dc.relation.ispartofseriesJournal of neonatal-perinatal medicine, 1878-4429, Vol. 9, Nro. 1, 2016, p. 31-39spa
dc.relation.urihttps://pubmed.ncbi.nlm.nih.gov/27002259/
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2016-03-24
dc.rights.localAcceso abiertospa
dc.subject.keywordsHypertension of pregnancyspa
dc.subject.keywordsTHBDspa
dc.subject.keywordsHistopathologyspa
dc.subject.keywordsmRNAspa
dc.titleIncreased tissue factor and thrombomodulin expression and histopathological changes in placentas of pregnancies with preeclampsiaspa
dc.title.translatedIncreased tissue factor and thrombomodulin expression and histopathological changes in placentas of pregnancies with preeclampsiaspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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