Human metapneumovirus infection is associated with severe respiratory disease in preschool children with history of prematurity

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dc.contributor.authorPancham, Krishna
dc.contributor.authorSami, Iman
dc.contributor.authorPerez, Geovanny F.
dc.contributor.authorHuseni, Shehlanoor
dc.contributor.authorKurdi, Bassem
dc.contributor.authorRose, Mary C.
dc.contributor.authorRodriguez-Martinez, Carlos E.
dc.contributor.authorNino, Gustavo
dc.date.accessioned2020-07-31T17:23:00Z
dc.date.available2020-07-31T17:23:00Z
dc.description.abstractenglishBackground: Human metapneumovirus (HMPV) is a recently discovered respiratory pathogen of the family Paramyxoviridae, the same family as that of respiratory syncytial virus (RSV). Premature children are at high risk of severe RSV infections, however, it is unclear whether HMPV infection is more severe in hospitalized children with a history of severe prematurity. Methods: We conducted a retrospective analysis of the clinical respiratory presentation of all polymerase chain reaction-confirmed HMPV infections in preschool-age children ( 5 years) with and without history of severe prematurity (<32 weeks gestation). Respiratory distress scores were developed to examine the clinical severity of HMPV infections. Demographic and clinical variables were obtained from reviewing electronic medical records. Results: A total of 571 preschool children were identified using polymerase chain reactionconfirmed viral respiratory tract infection during the study period. HMPV was identified as a causative organism in 63 cases (11%). Fiftyeeight (n Z 58) preschool-age children with HMPV infection were included in this study after excluding those with significant comorbidities. Our data demonstrated that 32.7% of children admitted with HMPV had a history of severe prematurity. Preschool children with a history of prematurity had more severe HMPV disease as illustrated by longer hospitalizations, new or increased need for supplemental O2, and higher severity scores independently of age, ethnicity, and history of asthma. Conclusion: Our study suggests that HMPV infection causes significant disease burden among preschool children with a history of prematurity leading to severe respiratory infections and increasing health care resource utilization due to prolonged hospitalizations.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://dx.doi.org/10.1016/j.pedneo.2015.03.008
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1875-9572
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3640
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalPediatrics and Neonatologyspa
dc.relation.ispartofseriesPediatrics and Neonatology, 1875-9572, Vol. 57, Nro. 1, 2016, p. 27-34spa
dc.relation.urihttps://www-clinicalkey-es.ezproxy.unbosque.edu.co/#!/content/playContent/1-s2.0-S1875957215000625?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1875957215000625%3Fshowall%3Dtrue&referrer=https:%2F%2Fresolver.ebscohost.com%2Fopenurl%3Fsid%3DEBSCO%253aedselp%26genre%3Darticle%26issn%3D18759572%26ISBN%3D%26volume%3D57%26issue%3D1%26date%3D20160201%26spage%3D27%26pages%3D27-34%26title%3DPediatrics%2B%26atitle%3DHuman%2BMetapneumovirus%2BInfection%2Bis%2BAssociated%2Bwith%2BSevere%2BRespiratory%2BDisease%2Bin%2BPreschool%2BChildren%2Bwith%2BHistory%2Bof%2BPrematurity%26aulast%3DPancham%252c%2BKrishna%26id%3DDOI%253a10.1016%252fj.pedneo.2015.03.008%26site%3Dftf-live%26SToken%3DA0IzzVd-e-bXaIGLQMWKf3RS4FPAIG40FMYEFosFqvXWGVvIcJOT1aNHpbU0qYkIMcryG6Rn9p-SuyncNi2r4ay3boqNVuo8NKNmpw55_z2F8zpHJEOSsY3pzgds646C7EwNzlVKDmkaSio-DEz3v43f3ptNtJNDBYKMgDAZkwS50gXQJw564u29xEigZw-4My4gg5v2TKJAHjzHfScGtylk0L1HSxtmCDdNoY5VGe-A7MFSXbEgvgx0JT03Zb3VAi8ixTEChPOxlrKpnjlpFnde0m9ankEw
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2016
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.keywordsAsthmaspa
dc.subject.keywordsHuman metapneumovirusspa
dc.subject.keywordsPrematurityspa
dc.subject.keywordsWheezingspa
dc.titleHuman metapneumovirus infection is associated with severe respiratory disease in preschool children with history of prematurityspa
dc.title.translatedHuman metapneumovirus infection is associated with severe respiratory disease in preschool children with history of prematurityspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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