Efficacy of local and systemic antimicrobials in the non-surgical treatment of smokers with chronic periodontitis: a systematic review

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dc.contributor.authorChambrone, Leandro
dc.contributor.authorVargas, Miguel
dc.contributor.authorarboleda, silie
dc.contributor.authorSerna, Maritza
dc.contributor.authorGuerrero, Marcela
dc.contributor.authorde Sousa, Jose
dc.contributor.authorLafaurie, Gloria Ines
dc.contributor.orcidLafaurie, Gloria Ines [0000-0003-3986-0625]
dc.contributor.orcidChambrone, Leandro [0000-0002-2838-1015]
dc.date.accessioned2020-11-18T17:50:09Z
dc.date.available2020-11-18T17:50:09Z
dc.description.abstractenglishThe aim of this systematic review is to evaluate whether use of local or systemic antimicrobials would improve clinical results of non‐surgical periodontal therapy for smokers with chronic periodontitis (CP). Medical Literature Analysis and Retrieval System Online, Excerpta Medica Database, and The Cochrane Central Register of Controlled Trials were searched up to and including March 2016. Randomized clinical trials of duration of at least 6 months were included if they reported on treatment of smokers (≥10 cigarettes per day for minimum 12 months) with CP with non‐surgical periodontal therapy either alone or associated with local or systemic antimicrobials. Random‐effects meta‐analyses were undertaken to evaluate mean differences in probing depth (PD) and clinical attachment level (CAL). Of 108 potentially eligible articles, seven were included. Most individual studies (75%) testing locally delivered antibiotics reported that smokers benefited from this treatment approach. Pooled estimates found additional PD reduction of 0.81 mm (P = 0.01) and CAL gain of 0.91 mm (P = 0.01) at sites with baseline PD ≥5 mm. Conversely, meta‐analysis on systemic use of antimicrobials failed to detect significant differences in mean changes from baseline, and only one trial supported their use. In smokers with CP, adjunctive use of local antimicrobials improved efficacy of non‐surgical periodontal therapy in reducing PD and improving CAL at sites presenting PD ≥5 mm before treatment. Current evidence does not demonstrate similar gains when scaling and root planing plus systemic antimicrobial/antibiotics were associated with therapy.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1902/jop.2016.160268
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1943-3670
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5083
dc.language.isoeng
dc.publisherWileyspa
dc.publisher.journalJournal of Periodontologyspa
dc.relation.ispartofseriesJournal of Periodontology, 1943-3670, Vol. 87, No. 11, 2016, p. 1320-1332spa
dc.relation.urihttps://aap.onlinelibrary.wiley.com/doi/abs/10.1902/jop.2016.160268
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2016
dc.rights.localAcceso abiertospa
dc.subject.keywordsAnti‐infective agentsspa
dc.subject.keywordsChronic periodontitisspa
dc.subject.keywordsDental scalingspa
dc.subject.keywordsReview literature as topicspa
dc.subject.keywordsRoot planing Smokingspa
dc.titleEfficacy of local and systemic antimicrobials in the non-surgical treatment of smokers with chronic periodontitis: a systematic reviewspa
dc.title.translatedEfficacy of local and systemic antimicrobials in the non-surgical treatment of smokers with chronic periodontitis: a systematic reviewspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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