Two‐dimensional and three‐dimensional models for studying atherosclerosis pathogenesis induced by periodontopathogenic microorganisms

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dc.contributor.authorGualtero, Diego Fernando
dc.contributor.authorLafaurie, Gloria Ines
dc.contributor.authorFontanilla, M.R.
dc.contributor.orcidLafaurie, Gloria Ines [0000-0003-3986-0625]
dc.contributor.orcidGualtero, Diego Fernando [0000-0002-6407-5605]
dc.date.accessioned2020-05-18T12:13:07Z
dc.date.available2020-05-18T12:13:07Z
dc.date.issued2018
dc.description.abstractenglishEpidemiological studies have established a clinical association between periodontal disease and atherosclerosis. Bacteremia and endotoxemia episodes in patients with periodontitis appear to link these two diseases by inducing a body‐wide production of cardiovascular markers. The presence of oral bacteria in atherosclerotic lesions in patients with periodontitis suggests that bacteria, or their antigenic components, induce alterations in the endothelium associated with atherosclerosis. Therefore, a causal mechanism explaining the association between both diseases can be constructed using in vitro models. This review presents current experimental approaches based on in vitro cell models used to shed light on the mechanism by which periodontal pathogenic microorganisms, and their antigenic components, induce proatherosclerotic endothelial activity. Monolayer cultures of endothelial vascular or arterial cells have been used to assess periodontal pathogenic bacteria and their antigenic compounds and endothelial activation. However, these models are not capable of reflecting the physiological characteristics of the endothelium inside vascularized tissue. Therefore, the shift from two‐dimensional (2D) cellular models toward three‐dimensional (3D) models of endothelial cells resembling an environment close to the physiological environment of the endothelial cell within the endothelium is useful for evaluating the physiological relevance of results regarding the endothelial dysfunction induced by periodontopathogens that are currently obtained from 2D models. The use of in vitro 3D cellular models can also be relevant to the search for therapeutic agents for chronic inflammatory diseases such as atherosclerosis. Here, we present some strategies for the assembly of 3D cultures with endothelial cells, which is useful for the study of periodontopathogen‐mediated disease.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/omi.12201
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2041-1014
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2951
dc.language.isoeng
dc.publisherWileyspa
dc.publisher.journalMolecular oral microbiologyspa
dc.relation.ispartofseriesMolecular oral microbiology, 2041-1014, Vol 33, Num 1, 2018, pag 29-37spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/full/10.1111/omi.12201
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2017
dc.rights.localAcceso cerradospa
dc.subject.decsArteriosclerosisspa
dc.subject.decsEnfermedades periodontalesspa
dc.subject.decsFactores de crecimiento endotelialspa
dc.subject.keywordsAtherosclerosisspa
dc.subject.keywordsEndothelial dysfunctionspa
dc.subject.keywordsLipopolysaccharidespa
dc.subject.keywordsPeriodontitisspa
dc.subject.keywordsPorphyromonas gingivalisspa
dc.titleTwo‐dimensional and three‐dimensional models for studying atherosclerosis pathogenesis induced by periodontopathogenic microorganismsspa
dc.title.translatedTwo‐dimensional and three‐dimensional models for studying atherosclerosis pathogenesis induced by periodontopathogenic microorganismsspa
dc.typearticlespa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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