The majority of a collection of U.S. Endocarditis enterococcus faecalis isolates obtained from 1974 to 2004 lack capsular genes and belong to diverse, non-hospital-associated lineages

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dc.contributor.authorChowdhury, Shahreen A.
dc.contributor.authorNallapareddy, Sreedhar R.
dc.contributor.authorArias, Cesar A.
dc.contributor.authorMurray, Barbara E.
dc.date.accessioned2020-07-16T20:34:58Z
dc.date.available2020-07-16T20:34:58Z
dc.date.issued2014
dc.description.abstractenglishEighty-one endocarditis-derived Enterococcus faecalis isolates that were collected from individual patients in the United States between 1974 and 2004 were sequence typed and analyzed for the presence of various genes, including some previously associated with virulence. Overall, using our previously described trilocus sequence typing (TLST), 44 different sequence types (STs) were found within this collection; 26 isolates were singletons (a unique TLST sequence type [STT]), some STTs contained multiple isolates (up to 6 isolates), and 16% of the isolates (13 isolates) could be grouped by additional sequence typing into clonal cluster 21 (CC21). Of note, only four isolates (7%) of the 56 whose multilocus sequence types were determined were found to belong to one of the previously described hospital-associated clonal clusters CC2 and CC9, and only 15% and 37% of all isolates had high-level resistance to gentamicin and streptomycin, respectively, including 10% that were resistant to both. We also found that 64% of the isolates lacked the genes for production of capsule polysaccharide, which has been proposed to enhance the pathogenic potential of the hospital-associated clonal clusters. In summary, while our collection is not a random sample of cases of E. faecalis endocarditis, these results indicate that nonencapsulated strains belonging to non-hospital-associated lineages were predominant among endocarditis E. faecalis isolates recovered during this time period.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://dx.doi.org/10.1128%2FJCM.02763-13
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1098-660X
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3543
dc.language.isoeng
dc.publisherAmerican Society for Microbiologyspa
dc.publisher.journalJournal of Clinical Microbiologyspa
dc.relation.ispartofseriesJournal of Clinical Microbiology, 1098-660X, Vol. 52, No. 2, 2014 p. 549-556spa
dc.relation.urihttps://jcm.asm.org/content/52/2/549.full
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2014-02
dc.rights.localAcceso abiertospa
dc.subject.decsEnterococcus faecalisspa
dc.subject.decsEndocarditisspa
dc.subject.decsInformes de casosspa
dc.titleThe majority of a collection of U.S. Endocarditis enterococcus faecalis isolates obtained from 1974 to 2004 lack capsular genes and belong to diverse, non-hospital-associated lineagesspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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