Acute toxicity evaluation of the ethanolic extract from leaves and flowers of chromolaena perglabra (b. l. robinson) king & h. rob.

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dc.contributor.authorCentanaro C., Nasly
dc.contributor.authorRubén D., Torrenegra G.
dc.contributor.authorLuis M., Pombo O.
dc.contributor.authorCadavid G., Vanessa
dc.contributor.authorRodríguez A., Oscar E
dc.date.accessioned2020-05-15T16:38:15Z
dc.date.available2020-05-15T16:38:15Z
dc.date.issued2018
dc.description.abstractenglishAt present, there is a great variety of plant species widely distributed in different geographical regions worldwide, with phytopharmacological potential; however, its indiscriminate use has limited access to vegetal resources by the population in general and the scientific community. Additionally, the lack of toxicological studies that provide knowledge on the safety of their use makes the problem more critical. According to traditional knowledge, the species that belong to the genus Chromolaena, have a high pharmacological potential, but currently, there are no studies that validate traditional use and safety. Therefore, the purpose of this investigation was to evaluate the acute toxicity of the leaf and flower extract of Chromolaena perglabra (C. perglabra) in mice. To develop this aim, 25 female ICR-CD1 mice were divided into two groups with three and two subgroups respectively, to which they were administered intraperitoneally 125, 250, 500, 1000 and 2000 mg / kg of the ethanolic extract of leaves and flowers of C. perglabra; another 5 mice were administered the vehicle (control group); 72 hours after inoculation, they were sacrificed for histopathological study (macroscopic and microscopic). An increase in size was observed with mild lymphoid hyperplasia in the spleen and toxic hepatitis in all the animals, the rest of the organs analyzed were in normal conditionseng
dc.format.mimetypeapplication/pdf
dc.identifier.issn1827-8620
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2828
dc.language.isoeng
dc.publisherSocietà Italo-Latinoamericana di Etnomedicinaspa
dc.publisher.journalPharmacologyOnLinespa
dc.relation.ispartofseriesPharmacologyOnLine, 1827-8620, Vol 3, 2018, pag 136-144spa
dc.relation.urihttps://pharmacologyonline.silae.it/front/archives_2018_3
dc.rights.creativecommons2018
dc.rights.localAcceso cerradospa
dc.subject.decsChromolaenaspa
dc.subject.decsPlantas medicinalesspa
dc.subject.decsMagnoliopsidaspa
dc.subject.keywordsAcute toxicityspa
dc.subject.keywordsChromolaena perglabraspa
dc.subject.keywordsAsteraceaespa
dc.subject.keywordsMedicinal plantsspa
dc.titleAcute toxicity evaluation of the ethanolic extract from leaves and flowers of chromolaena perglabra (b. l. robinson) king & h. rob.spa
dc.title.translatedAcute toxicity evaluation of the ethanolic extract from leaves and flowers of chromolaena perglabra (b. l. robinson) king & h. rob.spa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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