Bioacumulación de penicilinas, sulfamidas y fluoroquinolonas en peces: Una revisión bibliográfica de métodos analíticos para su detección, descripción de la biotransformación y toxicidad en peces
| dc.contributor.advisor | Becerra Figueroa, Liliana Marcela | |
| dc.contributor.author | Escudero Romero, Cielo Julieth | |
| dc.contributor.author | Becerra Figueroa, Liliana Marcela | |
| dc.contributor.orcid | Escudero Romero, Cielo Julieth [0009-0003-3286-8293] | |
| dc.contributor.orcid | Becerra Figueroa, Liliana Marcela [0000-0002-0459-3419] | |
| dc.date.accessioned | 2024-05-15T18:39:28Z | |
| dc.date.available | 2024-05-15T18:39:28Z | |
| dc.date.issued | 2024-05 | |
| dc.description.abstract | Se examinó la presencia de tres grupos de antibióticos (penicilinas, sulfonamidas y fluoroquinolonas) en peces mediante diversas técnicas cromatográficas. Para las penicilinas, se encontró únicamente un estudio que detectó amoxicilina en músculo de peces utilizando HPLC-MS/MS, en las sulfonamidas y fluoroquinolonas, predominó el uso de HPLC-MS/MS, UPLC-MS/MS y LC-MS/MS, en diversos tejidos de peces. Los procedimientos de preparación de muestras y las condiciones cromatográficas fueron muy similares entre estos grupos, el analizador de masas principal fue triple cuadrupolo acoplado a MRM, con fuentes de ionización ESI y API. Con relación a la bioacumulación, la ciprofloxacina mostró la mayor presencia entre las múltiples especies. La sulfadiazina también presentó altos niveles de bioacumulación, mientras que el sulfametoxazol y la Norfloxacina tuvieron una presencia moderada pero el LogBAF más alto (5,3). Las especies con mayor bioacumulación fueron las carpas, y los sitios más afectados fueron el río Amarillo y Mahegang, China, las branquias fue el tejido con la mayor bioacumulación, no se observó una relación significativa entre el coeficiente de reparto octanol-agua (Log P) y el factor de bioacumulación (log BAF). | |
| dc.description.abstractenglish | The presence of three groups of antibiotics (penicillins, sulfonamides and fluoroquinolones) in fish was examined by various chromatographic techniques. For penicillins, only one study was found that detected amoxicillin in fish muscle using HPLC-MS/MS; for sulfonamides and fluoroquinolones, the use of HPLC-MS/MS, UPLC-MS/MS and LC-MS/MS predominated in various fish tissues. Sample preparation procedures and chromatographic conditions were very similar among these groups, the main mass analyzer was triple quadrupole coupled to MRM, with ESI and API ionization sources. Regarding bioaccumulation, ciprofloxacin showed the highest presence among the multiple species. Sulfadiazine also showed high levels of bioaccumulation, while sulfamethoxazole and Norfloxacin had a moderate presence but the highest LogBAF (5.3). The species with the highest bioaccumulation were carp, and the most affected sites were the Yellow River and Mahegang, China, the gills was the tissue with the highest bioaccumulation, no significant relationship was observed between the octanol-water partition coefficient (Log P) and the bioaccumulation factor (log BAF). | |
| dc.description.degreelevel | Pregrado | spa |
| dc.description.degreelevel | Químico Farmacéutico | spa |
| dc.format.mimetype | application/pdf | |
| dc.identifier.instname | Universidad El Bosque | spa |
| dc.identifier.reponame | reponame:Repositorio Institucional Universidad El Bosque | spa |
| dc.identifier.repourl | repourl:https://repositorio.unbosque.edu.co | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12495/12119 | |
| dc.language.iso | es | |
| dc.publisher.faculty | Facultad de Ciencias | spa |
| dc.publisher.grantor | Universidad El Bosque | spa |
| dc.publisher.program | Química Farmacéutica | spa |
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| dc.rights | Atribución-NoComercial-CompartirIgual 4.0 Internacional | en |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | |
| dc.rights.local | Acceso abierto | spa |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.subject | Bioacumulación | |
| dc.subject | Penicilinas | |
| dc.subject | Sulfonamidas | |
| dc.subject | Fluoroquinolonas | |
| dc.subject | Cromatografía líquida | |
| dc.subject | Espectrofotometría de masas | |
| dc.subject | Toxicidad | |
| dc.subject.ddc | 615.19 | |
| dc.subject.keywords | Bioaccumulation | |
| dc.subject.keywords | Penicillins | |
| dc.subject.keywords | Sulfonamides | |
| dc.subject.keywords | Fluoroquinolones | |
| dc.subject.keywords | Liquid chromatography | |
| dc.subject.keywords | Mass spectrophotometry | |
| dc.subject.keywords | Toxicity | |
| dc.title | Bioacumulación de penicilinas, sulfamidas y fluoroquinolonas en peces: Una revisión bibliográfica de métodos analíticos para su detección, descripción de la biotransformación y toxicidad en peces | |
| dc.title.translated | Bioaccumulation of penicillins, sulfonamides and fluoroquinolones in fish: A literature review of analytical methods for their detection, description of biotransformation and toxicity in fish | |
| dc.type.coar | https://purl.org/coar/resource_type/c_7a1f | |
| dc.type.coarversion | https://purl.org/coar/version/c_ab4af688f83e57aa | |
| dc.type.driver | info:eu-repo/semantics/bachelorThesis | |
| dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | |
| dc.type.local | Tesis/Trabajo de grado - Monografía - Pregrado |